EC Number |
Substrates |
Products |
Reversibility |
---|
1.1.1.169 | (R)-4-dehydropantoate + NADPH + H+ |
- |
(R)-pantoate + NADP+ |
- |
? |
1.1.1.169 | (R)-pantoate + NAD+ |
- |
2-dehydropantoate + NADH + H+ |
- |
r |
1.1.1.169 | (R)-pantoate + NADP+ |
- |
2-dehydropantoate + NADPH + H+ |
- |
r |
1.1.1.169 | (R)-pantoate + NADP+ |
substrate binding structure analysis, overview |
2-dehydropantoate + NADPH + H+ |
- |
r |
1.1.1.169 | (S)-pantoate + NAD+ |
low activity |
2-dehydropantoate + NADH + H+ |
- |
r |
1.1.1.169 | (S)-pantoate + NADP+ |
low activity |
2-dehydropantoate + NADPH + H+ |
- |
r |
1.1.1.169 | 2-dehydropantoate + NADH + H+ |
- |
(R)-pantoate + NAD+ |
- |
r |
1.1.1.169 | 2-dehydropantoate + NADH + H+ |
the TK1968 protein displays reductase activity specific for 2-oxopantoate and prefers NADH as the electron donor, distinct to the bacterial/eukaryotic NADPH-dependent enzymes |
(R)-pantoate + NAD+ |
- |
r |
1.1.1.169 | 2-dehydropantoate + NADPH |
- |
(R)-pantoate + NADP+ |
- |
? |
1.1.1.169 | 2-dehydropantoate + NADPH |
an essential step for the biosynthesis of pantothenate, i.e. vitamin B5 |
(R)-pantoate + NADP+ |
- |
r |