EC Number |
Recommended Name |
Substrates |
Organism |
Products |
---|
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-alpha-estradiol |
very high activity with UGT1A10 |
Homo sapiens |
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-beta-estradiol |
- |
Homo sapiens |
UDP + 17-beta-estradiol 3-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-beta-estradiol |
low activity |
Homo sapiens |
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-beta-estradiol |
lower activity |
Homo sapiens |
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-beta-estradiol |
very high activity |
Homo sapiens |
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17beta-estradiol |
- |
Homo sapiens |
UDP + 17beta-estradiol 3-O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 3,17-estradiol |
isozyme UGT1A1 |
Homo sapiens |
UDP + 17-estradiol 3-O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 3,17-estradiol |
isozyme UGT1A1 |
Homo sapiens |
UDP + 3-estradiol 17-O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 4-hydroxyestradiol |
- |
Homo sapiens |
UDP + 4-hydroxyestradiol beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + beta-estradiol |
- |
Homo sapiens |
UDP + estradiol 3-beta-D-glucuronide |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + estradiol |
- |
Homo sapiens |
UDP + estradiol beta-D-glucuronide |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + estradiol |
- |
Homo sapiens |
UDP + estradiol beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + estradiol |
the enzyme UGT1A9 is active with estrogens |
Homo sapiens |
UDP + estradiol beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + ethinylestradiol |
isozyme UGT1A1 |
Homo sapiens |
UDP + ethinylestradiol glucuronide |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + ethinylestradiol |
- |
Homo sapiens |
UDP + ethinylestradiol beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + ethinylestradiol |
very low activity |
Homo sapiens |
UDP + ethinylestradiol beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronic acid + beta-estradiol |
UGT1A3 |
Homo sapiens |
UDP + beta-estradiol 3-O-beta-D-glucuronide |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol |
- |
Homo sapiens |
? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1A1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1A3 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1A2 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1C*2 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 2-methoxyestradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol sulfate |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylylsulfate + beta-estradiol |
ST1A3 and ST1A5 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylylsulfate + beta-estradiol |
no activity: ST1B2 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.2 | alcohol sulfotransferase |
3'-phosphoadenylylsulfate + 17-beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate |
2.8.2.2 | alcohol sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17alpha-ethinylestradiol sulfate |
2.8.2.2 | alcohol sulfotransferase |
3'-phosphoadenylylsulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-O-sulfate |
2.8.2.4 | estrone sulfotransferase |
17beta-estradiol + 3'-phosphoadenylyl sulfate |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
17beta-estradiol regulates growth and differentiation in normal and malignant bone, it is inactivated to 17beta-estradiol-sulfate through SULT1E1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1E1 has a high affinity and catalytic efficiency for estradiol as substrate |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
SULT1E1 is involved in estrogen inactivation |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
high activity by SULT1E1, low activity by SULT1A1, EC 2.8.2.1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
isozyme SULT1E1 is specific for estradiol sulfonation, interaction of resveratrol with 17beta-estradiol, overview |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
EST expression and regulation in invasive breast cancer and ductal carcinoma in situ, overview |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
estradiol sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
SULT1E1 acts at nanomolar concentration of estradiol. SULT1A1 is active at micromolar concentration of estradiol and has an affinity 300fold lower than SULT1E1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + ethinyl estradiol |
a synthetic oral contraceptive, low activity |
Homo sapiens |
adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol |
isoform SULT1A3 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
best substrate |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.14 | bile-salt sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 16-hydroxy-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-estradiol |
estra-1,3,5(10)-triene-3,17alpha-diol |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-ethynylestradiol |
celecoxib switches sulfation from the 3-O-position to the 17beta-O-position |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17alpha-ethynylestradiol 3-sulfate |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
estra-1,3,5(10)-triene-3,17alpha-diol |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 2-hydroxy-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 4-hydroxy-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
3.1.6.2 | steryl-sulfatase |
17beta-estradiol sulfate + H2O |
- |
Homo sapiens |
17beta-estradiol + sulfate |
3.2.1.21 | beta-glucosidase |
17beta-estradiol 17-beta-D-glucoside + H2O |
- |
Homo sapiens |
beta-D-glucose + 17beta-estradiol |
3.2.1.21 | beta-glucosidase |
17beta-estradiol-3'-beta-D-glucoside + H2O |
poor activity |
Homo sapiens |
beta-D-glucose + 17beta-estradiol |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + 17beta-estradiol 17-(beta-D-glucuronide)/in |
- |
Homo sapiens |
ADP + phosphate + 17beta-estradiol 17-(beta-D-glucuronide)/out |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + 17beta-estradiol 17-(beta-D-glucuronide)/in |
transported by MRP1 and MRP3 |
Homo sapiens |
ADP + phosphate + 17beta-estradiol 17-(beta-D-glucuronide)/out |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + 17beta-glucuronosyl oestradiol/in |
- |
Homo sapiens |
ADP + phosphate + 17beta-glucuronosyl oestradiol/out |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + estradiol 17-beta-D-glucuronide/in |
- |
Homo sapiens |
ADP + phosphate + estradiol 17-beta-D-glucuronide/out |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + estradiol glucuronide/in |
- |
Homo sapiens |
ADP + phosphate + estradiol glucuronide/out |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + estradiol[side 1] |
substrate for MRP1 |
Homo sapiens |
ADP + phosphate + estradiol[side 2] |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + ethinylestradiol-3-O-glucuronide[side 1] |
substrate for MPR2 |
Homo sapiens |
ADP + phosphate + ethinylestradiol-3-O-glucuronide[side 2] |
7.6.2.2 | ABC-type xenobiotic transporter |
estradiol 17-beta-D-glucuronide/in + ATP + H2O |
- |
Homo sapiens |
estradiol 17-beta-D-glucuronide/out + ADP + phosphate |
7.6.2.3 | ABC-type glutathione-S-conjugate transporter |
ATP + H2O + S-(17beta-estradiol)glutathione[side 1] |
substrate for isoform MRP4 |
Homo sapiens |
ADP + phosphate + S-(17beta-estradiol)glutathione[side 2] |
7.6.2.3 | ABC-type glutathione-S-conjugate transporter |
ATP + H2O + S-(17beta-glucuronosyl estradiol)glutathione[side 1] |
- |
Homo sapiens |
ADP + phosphate + S-(17beta-glucuronosyl estradiol)glutathione[side 2] |