EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.22.B75 | more |
SENP7 reveals no detectable endopeptidase activity on the precursors of ubiquitin, Nedd8 and ISG15 |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | more |
a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent |
Mus musculus |
? |
- |
? |
| 3.4.22.B75 | more |
the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1 |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | more |
isozyme SENP7 shows isoform specificity for SUMO2/3 over SUMO1 |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | more |
long enzyme variant SENP7L, but not short enzyme variant SENP7S, binds HP1alpha. This interaction does not require catalytic activity: both the active wild-type SENP7L and the catalytically inactive mutant (SENP7Lm) bind endogenous HP1alpha efficiently |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | more |
SENP7 is a SUMO protease with a preference for deconjugating SUMO2 and SUMO3, particularly in a polymeric form. Precursor SUMO1, SUMO2 and SUMO3 and SUMO1 polymers are poorly processed by SENP7 |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | poly-SUMO-2 + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | poly-SUMO-2 + H2O |
the C-terminal catalytic domain of SENP7 efficiently depolymerized poly-SUMO-2 chains but has undetectable activity against poly-SUMO-1 chains |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | poly-SUMO-3 + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.4.22.B75 | polySUMO2 KRAB-associated protein 1 + H2O |
enzyme SENP7 promotes the removal of SUMO2 from KRAB-associated protein 1 |
Homo sapiens |
KRAB-associated protein 1 + SUMO 2 + SUMO3 |
- |
? |
