EC Number   |
Substrates  |
Organism |
Products |
Reversibility |
|---|
   3.4.21.7 | ADAMTS13 + H2O |
inactivation |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | AIYRSR + H2O |
- |
Homo sapiens |
AIYR + Ser-Arg |
- |
? |
| 3.4.21.7 | alpha-lactalbumin + H2O |
hydrolysis is highly dependent on photooxidation state of substrate |
Bos taurus |
? |
- |
? |
| 3.4.21.7 | alphaS-casein + H2O |
hydrolysis is highly dependent on photooxidation state of substrate |
Bos taurus |
? |
- |
? |
| 3.4.21.7 | alphas1-casein + H2O |
- |
Bos taurus |
? |
- |
? |
| 3.4.21.7 | amyloid beta peptide Abeta42 + H2O |
cleavage prevents the aggregation of Abeta42 and its cleavage products into beta-pleated sheet structure |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | amyloid-beta + H2O |
plasmin cleaves at multiple sites |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | amyloid-beta + H2O |
the plasmin pathway is induced by aggregated amyloid-beta, which can lead to amyloid-beta degradation and inhibition of amyloid-beta actions |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | annexin A2 + H2O |
interaction of plasmin with annexin A2 results in the stimulation of ERK1/2 and p38 MAPK, cyclooxygenase-2, and PGE(2), leading to increased matrix metalloproteinase-1 production |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | annexin A2 + H2O |
stimulation of macrophages with plasmin leads to cleavage of ca. 6% of annexin A2 yielding a proteolytic fragment of ca. 33 kDa |
Homo sapiens |
? |
- |
? |
