EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Homo sapiens |
leukotriene B4 |
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% |
? |
| 3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Rattus norvegicus |
leukotriene B4 |
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% |
? |
| 3.3.2.6 | more |
neutrophil LTA4 hydrolase also converts LTA5 to LTB5, less efficiently than LTA4 to LTB4 |
Homo sapiens |
? |
- |
? |
| 3.3.2.6 | more |
no activity with L-Asn, L-Asp, L-Glu, Gly, L-Ile, L-Thr, L-Trp, L-Val, as well as D-amino acids |
Homo sapiens |
? |
- |
? |
| 3.3.2.6 | more |
not: glycine-4-nitroanilide, glutamyl-4-nitroanilide, valine-4-nitroanilide |
Homo sapiens |
? |
- |
? |
| 3.3.2.6 | leukotriene A4 + H2O |
one of the physiologically important processes in the arachidonic acid biosynthetic pathway, leukotriene B4 is a proinflammatory mediator which stimulates adhesion of circulating neutrophils to vascular endothelium and directs their migration towards sites of inflammation |
Homo sapiens |
leukotriene B4 |
- |
? |
| 3.3.2.6 | proline-glycine-proline + H2O |
PGP |
Homo sapiens |
? |
- |
? |
| 3.3.2.6 | more |
possible proteolytic function of the enzyme may be limited to the extracellular space |
Homo sapiens |
? |
- |
? |
| 3.3.2.6 | more |
proline-glycine-proline (PGP) is a substrate for the enzyme's aminopeptidase (AP) activity |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.6 | more |
proline-glycine-proline (PGP) is a substrate for the enzyme's aminopeptidase (AP) activity |
Homo sapiens |
? |
- |
? |
