EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.1.1.77 | 3-(acyloxy)acyl group of bacterial toxin + H2O |
- |
Oryctolagus cuniculus |
3-hydroxyacyl group of bacterial toxin + a fatty acid |
- |
? |
| 3.1.1.77 | 3-(acyloxy)acyl group of bacterial toxin + H2O |
smooth LPS deacylated more slowly than rough LPS |
Homo sapiens |
3-hydroxyacyl group of bacterial toxin + a fatty acid |
palmitoleate released more slowly than myristate and laurate, 2-hydroxylaurate released more slowly than laurate |
? |
| 3.1.1.77 | 3-(acyloxy)acyl group of bacterial toxin + H2O |
host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice |
Mus musculus |
3-hydroxyacyl group of bacterial toxin + a fatty acid |
- |
? |
| 3.1.1.77 | 3-(acyloxy)acyl group of bacterial toxin + H2O |
detoxification of lipopolysaccharide |
Mus musculus |
3-hydroxyacyl group of bacterial toxin + a fatty acid |
- |
? |
| 3.1.1.77 | diacylglycerol + H2O |
in vitro |
Homo sapiens |
? |
- |
? |
| 3.1.1.77 | diacylphosphatidylethanolamine + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.1.1.77 | glycerophospholipid + H2O |
in vitro |
Homo sapiens |
? |
- |
? |
| 3.1.1.77 | lipopolysaccharide + H2O |
- |
Mus musculus |
? |
- |
? |
| 3.1.1.77 | lipopolysaccharide + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.1.1.77 | lipopolysaccharide + H2O |
- |
Oryctolagus cuniculus |
? |
- |
? |
