EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine |
both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide |
Escherichia coli |
protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl radicals |
- |
? |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine |
octanoylated pyruvate dehydrogenase E2 domain |
Escherichia coli |
protein N6-(lipoyl)lysine + 2 L-methionine + 5'-deoxyadenosyl radical |
- |
? |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine |
lipoyl-bearing subunit of the glycine cleavage system (H-protein) is a substrate for LipA. 5'-deoxyadenosyl radical acts directly on the octanoyl substrate. 2 equivalents of S-adenosyl-L-methionine are cleaved irreversibly in forming 1 equivalent of [lipoyl]H-protein and are consistent with a model in which two LipA proteins are required to synthesize one lipoyl group |
Escherichia coli |
protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosyl radicals |
- |
ir |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine |
tetrapeptide substrate, containing an Nepsilon-octanoyl lysine residue, corresponding in sequence to the lipoyl binding domain of the E2 subunit of pyruvate dehydrogenase |
Saccharolobus solfataricus |
protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosyl radicals |
- |
? |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine |
- |
Bacillus subtilis |
protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine |
- |
? |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine |
- |
Bacillus subtilis |
protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine |
- |
ir |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine |
- |
Arabidopsis thaliana |
protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine |
- |
? |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] ferredoxin |
- |
Mycobacterium tuberculosis |
protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] ferredoxin |
- |
? |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster |
- |
Thermus thermophilus |
protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster |
- |
? |
2.8.1.8 | protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster |
- |
Escherichia coli |
protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster |
- |
? |