EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. formalin-induced inflammatory pain and thermal hyperalgesia, overview |
Mus musculus |
? |
- |
? |
| 2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is linked to the cell cycle machinery, constitutive phosphorylation and activation of the enzyme leads to cell proliferation in choroidal melanoma cells |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | more |
MKK7gamma1 is unable to phosphorylate p38 |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | more |
adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway, overview |
Rattus norvegicus |
? |
- |
? |
| 2.7.12.2 | more |
Arabidopsis thaliana mitogen-activated protein kinase kinase MKK1 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. The mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes |
Arabidopsis thaliana |
? |
- |
? |
| 2.7.12.2 | more |
Arabidopsis thaliana mitogen-activated protein kinase kinase MKK2 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. mkk2 single mutants appear morphologically normal, the mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes |
Arabidopsis thaliana |
? |
- |
? |
| 2.7.12.2 | more |
lithium protection of phencyclidine-induced neurotoxicity and cell death in developing brain: the role of phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways, overview |
Rattus norvegicus |
? |
- |
? |
| 2.7.12.2 | more |
MAP kinase kinase 1 is regulated by salt and drought stresses, differential expression, overview |
Oryza sativa |
? |
- |
? |
| 2.7.12.2 | more |
MAP kinase kinase 10-2 is regulated only by cold stress, differential expression, overview |
Oryza sativa |
? |
- |
? |
| 2.7.12.2 | more |
MAP kinase kinase 6 is strongly regulated by cold and salt stresses, differential expression, overview |
Oryza sativa |
? |
- |
? |
