EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. formalin-induced inflammatory pain and thermal hyperalgesia, overview |
Mus musculus |
? |
- |
? |
| 2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is linked to the cell cycle machinery, constitutive phosphorylation and activation of the enzyme leads to cell proliferation in choroidal melanoma cells |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | ATP + protein |
the enzyme is involved in the mitogenic growth factor signal transduction pathway in vertebrates |
Gallus gallus |
ADP + phosphoprotein |
- |
? |
| 2.7.12.2 | ATP + protein |
the enzyme is required for locus-dependent and locus-independent steps in the fungal life cycle. Necessary for locus-dependent processes, such as conjugation tube formation, filament formation, and maintenance of filamentous growth, and for locus-independent processes, such as tumor induction and teliospore germination |
Ustilago maydis |
ADP + phosphoprotein |
- |
? |
| 2.7.12.2 | ATP + protein |
the enzyme is the major activator of RK/p38 |
Homo sapiens |
ADP + phosphoprotein |
- |
? |
| 2.7.12.2 | more |
the enzyme performs autophosphorylation |
Leishmania mexicana |
? |
- |
? |
| 2.7.12.2 | ATP + Pfmap2 |
the enzyme phosphorylates its potential in vivo Pfmap2 substrate largely on Thr290 |
Plasmodium falciparum |
ADP + phosphorylated Pfmap2 |
- |
? |
| 2.7.12.2 | ATP + protein |
the enzyme renders the cell resistant to polymyxin B |
Saccharomyces cerevisiae |
ADP + phosphoprotein |
- |
? |
| 2.7.12.2 | ATP + protein |
the enzyme undergoes autophosphorylation on Ser, Thr and Tyr |
Xenopus laevis |
ADP + phosphoprotein |
- |
? |
| 2.7.12.2 | more |
the MEKK-1 is involved in stress-induced cell death of insulin-producing cells and essential in JNK activation, overview |
Homo sapiens |
? |
- |
? |
