EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.11.15 | more |
G protein-coupled receptors and Toll-like receptors play a crucial role in the regulation of macrophage biology and innate immunity, overview |
Mus musculus |
? |
- |
? |
| 2.7.11.15 | more |
Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo, i.e. Smoothened, signal transduction pathway, overview. When Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Regulation of Gprk2 expression by Hh signaling in the wing disc, but Gprk2 is also required for Hh signaling in the wing disc, overview |
Drosophila melanogaster |
? |
- |
? |
| 2.7.11.15 | more |
GRK-mediated desensitization of beta2-adrenergic receptors is sufficient to cause declines in cAMP signals. GRK-mediated desensitization is primarily responsible for a sustained suppression of beta2AR signaling, overview |
Homo sapiens |
? |
- |
? |
| 2.7.11.15 | more |
GRK2 causes enhanced catecholamine secretion by desensitizing sympatho-inhibitory alpha2-adrenergic receptors of chromaffin cells and thereby aggravating heart failure |
Rattus norvegicus |
? |
- |
? |
| 2.7.11.15 | more |
GRK2 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by their carboxyl-terminal pleckstrin homology domain, overview |
Mus musculus |
? |
- |
? |
| 2.7.11.15 | more |
GRK2 is important for myocardial regulation, and is up-regulated in the dysfunctional heart |
Mus musculus |
? |
- |
? |
| 2.7.11.15 | more |
GRK2 substrate specificity in adult rat cardiac myocytes, overview. GRK2 completely lacks the capacity to attenuate phenylephrine-stimulated IP generation |
Rattus norvegicus |
? |
- |
? |
| 2.7.11.15 | more |
GRK3 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by its carboxyl-terminal pleckstrin homology domain. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness, distinct functions of GRK3 in regulation of cardiac contractility and growth, overview |
Mus musculus |
? |
- |
? |
| 2.7.11.15 | more |
GRK3 substrate specificity in adult rat cardiac myocytes, overview |
Rattus norvegicus |
? |
- |
? |
| 2.7.11.15 | more |
GRK2 also phosphorylates rhodopsin, cf. EC 2.7.11.14 |
Homo sapiens |
? |
- |
? |
