EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.10 | ATP + a protein |
autophosphorylation at both Ser and Thr |
Myxococcus xanthus |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection |
Mus musculus |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
the expression of pkn1 is developmentally regulated to start immediately before spore formation. The enzyme plays an important role in the onset of proper differentiation |
Myxococcus xanthus |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses |
Mus musculus |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + Bcl |
phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling |
Mus musculus |
ADP + phosphorylated Bcl |
- |
? |
2.7.11.10 | ATP + Bcl |
phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling |
Homo sapiens |
ADP + phosphorylated Bcl |
- |
? |