EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.10 | ATP + Bcl |
phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl |
Mus musculus |
ADP + phosphorylated Bcl |
- |
? |
2.7.11.10 | ATP + Bcl |
phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl |
Homo sapiens |
ADP + phosphorylated Bcl |
- |
? |
2.7.11.10 | ATP + Bcl |
Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl |
Homo sapiens |
ADP + phosphorylated Bcl10 |
- |
? |
2.7.11.10 | ATP + Bcl10 |
negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview |
Homo sapiens |
ADP + phosphorylated Bcl10 |
- |
? |
2.7.11.10 | ATP + GST-IkappaBalpha |
activity assay |
Homo sapiens |
ADP + GST-IkappaBalpha phosphoprotein |
- |
? |
2.7.11.10 | ATP + IkappaB alpha |
- |
Homo sapiens |
ADP + phosphorylated IkappaB alpha |
- |
? |
2.7.11.10 | ATP + IkappaB protein |
the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages |
Mus musculus |
ADP + phosphorylated IkappaB |
- |
? |
2.7.11.10 | ATP + IkappaB protein |
- |
Homo sapiens |
ADP + IkappaB phosphoprotein |
- |
? |
2.7.11.10 | ATP + IkappaBalpha |
- |
Homo sapiens |
ADP + phosphorylated IkappaBalpha |
- |
? |
2.7.11.10 | ATP + IkappaBalpha |
a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer |
Homo sapiens |
ADP + phosphorylated IkappaBalpha |
- |
? |