EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   2.7.11.10 | more |
IKK is involved in NF-kappaB activation, IkappaB kinase IKKbeta, but not IKKalpha, is a critical mediator of NF-kappaB-dependent osteoclast survival preventing TNFalpha-induced cell death, and is required for formation of fully functional bone-resorbing osteoclasts and for inflammation-induced bone loss |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
IKK is required for activation of NF-kappaB and subsequent signalling pathways |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
IKK is responsible for activation of NFkappaB, herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
IKK is responsible for NF-kappaB activation by inactivating its inhibitor IkappaB, different inflammation stimuli induce distinct IKK activity profiles, molecular mechanism, overview |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
IKK marks cytoplasmic NFkappaB inhibitors for proteolytic destruction playing a role in regulation of genetic cell cycle programs, IKK regulates nuclear translocation of transcription factor NFkappaB |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
IKKbeta is required for activation of NFkappaB, IKKbeta induces expression of epithelial sodium channel alphabetagamma-ENaC in cell surfaces |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
IKKbeta is required for regulation of NFkappaB activity and peripheral B cell survival and proliferation |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
IKKbeta regulates the translocation of NF-kappaB from cytoplasm to nucleus earmarking the transcription factor for polyubiquitination and proteasome-mediated degradation, the cytokine TNFalpha-induced T-loop-phosphorylated IKKbeta becomes monoubiquitinated at Lyk163 proximal to the T-loop, mechanism of post-translational crosstalk, overview |
Homo sapiens |
? |
- |
? |
