EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.10 | ATP + [MYPT1] |
the enzyme phosphorylates MYPT1 at Thr853 |
Rattus norvegicus |
ADP + [MYPT1 phosphoprotein] |
- |
? |
2.7.11.10 | ATP + IkappaB protein |
the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages |
Mus musculus |
ADP + phosphorylated IkappaB |
- |
? |
2.7.11.10 | ATP + a protein |
the expression of pkn1 is developmentally regulated to start immediately before spore formation. The enzyme plays an important role in the onset of proper differentiation |
Myxococcus xanthus |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection |
Homo sapiens |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | ATP + a protein |
the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection |
Mus musculus |
ADP + a phosphoprotein |
- |
? |
2.7.11.10 | more |
the IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories, IKKalpha is involved in the regulation of histone H3 phosphorylation and acetylation at specific gene promoters in hippocampus in the NF-kappaB pathway, inhibition of IKKalpha regulation results in impairments in fear memory reconsolidation, mechanism, overview |
Rattus norvegicus |
? |
- |
? |
2.7.11.10 | ATP + [IkappaB protein] |
the IkappaBalpha subunit of NF-kappaB is phosphorylated at serine residues 32 and 36 |
Homo sapiens |
ADP + [IkappaB phosphoprotein] |
- |
? |
2.7.11.10 | more |
the IKK complex is responsible for NFkappaB regulation |
Homo sapiens |
? |
- |
? |
2.7.11.10 | ATP + [S386A IFN regulatory factor 3 protein] |
the mutant substrate is equally phosphorylated as the wild-type IRF3 |
Mus musculus |
ADP + [S386A IFN regulatory factor 3 phosphoprotein] |
- |
? |
2.7.11.10 | ATP + [S396A IFN regulatory factor 3 protein] |
the mutant substrate is equally phosphorylated as the wild-type IRF3 |
Mus musculus |
ADP + [S396A IFN regulatory factor 3 phosphoprotein] |
- |
? |