EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.11.10 | more |
IKKbeta is required for regulation of NFkappaB activity and peripheral B cell survival and proliferation |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
IKKbeta regulates the translocation of NF-kappaB from cytoplasm to nucleus earmarking the transcription factor for polyubiquitination and proteasome-mediated degradation, the cytokine TNFalpha-induced T-loop-phosphorylated IKKbeta becomes monoubiquitinated at Lyk163 proximal to the T-loop, mechanism of post-translational crosstalk, overview |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
infection and genome insertion of human cytomegalovirus induces expression of the catalytic subunit IKK2 in the host cell which is required for viral induction of NF-kappaB activation and involved in viral replication and lytic cycle |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
parasite Toxoplasma gondii IKKalpha, localized in parasitophorous vacuole membrane, activates the host intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
subunit IKKbeta controls the activation of NF-kappaB, important in inflammation, IKKalpha plays a role in lyphoid organogenesis and suppresses NF-kappaB activity by accelerating both the turnover of the NFkappaB subunits RelA and c-Rel, and their removal from pro-inflammatory gene promoters, inactivation of IKKalpha enhances inflammation and bacterial clearance in mice, overview |
Mus musculus |
? |
- |
? |
| 2.7.11.10 | more |
the IKK complex is responsible for NFkappaB regulation |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
the noncanonical IkappaB kinase homologue IKKepsilon, beneath TANK-binding kinase-1 TBK-1, is required for activation of transcription factor NFkappaB and of interferon regulatory factor 3 IRF3, regulation and interaction, overview |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
Vav-1 and IKKalpha subunit of IkappaB kinase functionally associate to induce NFkappaB activation in response to CD28 engagement |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
TNF-R1-activated IKKbeta phosphorylates IKKgamma and IKKalpha, autophosphorylation patterns involving K163 of IKKbeta, regulation, overview |
Homo sapiens |
? |
- |
? |
| 2.7.11.10 | more |
activated IKK2 is responsible for induction of leucocyte infiltration in pancreatic acini, the mutant ICC2CA in pancreatic acinar cells increases tissue damage of secretagogue induced experimental pancreatitits, the enzyme is involved in the proinflammatory IKK/NF-kappaB pathway, overview |
Mus musculus |
? |
- |
? |
