EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.10.2 | more |
Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin |
Homo sapiens |
? |
- |
? |
| 2.7.10.2 | more |
Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin |
Rattus norvegicus |
? |
- |
? |
| 2.7.10.2 | more |
Syk affects actin dynamics around the C3bi-mediated phagosomes |
Homo sapiens |
? |
- |
? |
| 2.7.10.2 | more |
the enzyme is activated by phosphorylation, and also performs autophosphorylation |
Homo sapiens |
? |
- |
? |
| 2.7.10.2 | more |
the enzyme performs autophosphorylation at tyrosine residues |
Homo sapiens |
? |
- |
? |
| 2.7.10.2 | more |
Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis, Lyn and and its interaction with rafts and TLR2 are involved in the initial stages of Pseudomonas aeruginosa interaction with host cells and invasion of an alveolar epithelial cell line, primary lung cells, and rat lungs by Pseudomonas aeruginosa, overview |
Pseudomonas aeruginosa |
? |
- |
? |
| 2.7.10.2 | more |
SH2 domain-based tyrosine kinase assay using biotin ligase modified with a terbium(III) complex. An SH2 domain from lymphocyte-specific tyrosine kinase is genetically fused to a truncated biotin carboxyl carrier protein, and the resulting fusion protein is labeled through biotinylation with biotin protein ligase carrying multiple copies of a luminescent Tb3+ complex. The labeled SH2 fusion proteins are employed to detect a phosphorylated peptide immobilized on the surface of the microtiter plate, where the phosphorylated peptide is produced by phosphorylation to the substrate peptide by Src tyrosine kinase. The assay allows for a reliable determination of the activity of Src kinase lower than 10 ng/mL |
Sulfurisphaera tokodaii |
? |
- |
? |
| 2.7.10.2 | more |
after platelet stimulation, integrin alphaIIbbeta3 binds to the enzyme's SH3 domain at a site overlapping with its PPII helix binding site |
Homo sapiens |
? |
- |
? |
| 2.7.10.2 | more |
the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity |
Mus musculus C57BL/6 |
? |
- |
? |
| 2.7.10.2 | more |
p40mos binds ATP analog p-fluorosulfonylbenzoyladenosine and exhibits ATPase activity |
Moloney murine sarcoma virus HT-1 |
? |
- |
? |
