EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.4.2.30 | more |
exoenzyme S and 14-3-3 interact in a direct fashion, interaction involves the conserved amphiphatic groove of 14-3-3 |
Pseudomonas aeruginosa |
? |
- |
? |
2.4.2.30 | more |
exoenzyme S is an important adhesin |
Pseudomonas aeruginosa |
? |
- |
? |
2.4.2.30 | more |
ExoS is a virulence factor of the pathogen |
Pseudomonas aeruginosa |
? |
- |
? |
2.4.2.30 | more |
PARP-1 inhibits the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP. Inhibition of TonEBP/OREBP transcriptional activity by PARP-1 does not require PARP-1 catalytic activity, functional interaction anaylsis, overview |
Homo sapiens |
? |
- |
? |
2.4.2.30 | more |
PARP-1 is involved in modulation of NO-derived injury and response to genotoxic damage |
Mus musculus |
? |
- |
? |
2.4.2.30 | more |
PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview |
Mus musculus |
? |
- |
? |
2.4.2.30 | more |
PARP-1 plays fundamental roles in the recruitment and modulation of enzymatic and regulatory factors involved in transcription, DNA replication, repair and recombination, the enzyme antagonizes topoisomerase I-dependent recombination stimulation by P53 |
Mus musculus |
? |
- |
? |
2.4.2.30 | more |
PARP-1 responds to DNA damage by transferring 50 to 200 molecules of ADP-ribose to various nuclear proteins, including transcription factors, histones and PARP-1 itself, interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition, ATM and PARP-1 are two of the most important players in the cell's response to DNA damage, PARP-1 is needed for optimal activation of ATM, overview |
Mus musculus |
? |
- |
? |
2.4.2.30 | more |
Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T-dependent manner, the ADP-ribosyl transferase domain inhibits late steps of cytokinesis by blocking syntaxin-2 localization to the midbody, an event essential for completion of cytokinesis, e.g. in Madin-Darby canine kidney cells, mechanism, overview |
Pseudomonas aeruginosa |
? |
- |
? |
2.4.2.30 | more |
role for PARP-1 in DNA double-strand break repair, the enzyme is not required for homologous recombination itself, it regulates the process through its involvement in the repair of DNA single-strand breaks, PARP-1 binds to DNA breaks to facilitate DNA repair, but the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, DNA binding and auto-modification of PARP-1 attracts the DNA repair proteins |
Mus musculus |
? |
- |
? |