EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
methylation site is experimentally determined as guanine1405 by MALDI-ToF mass spectrometry |
Micromonospora zionensis |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
methylation at guanine1405 mediates cellular resistance by blocking aminoglycoside binding by ribosomes |
plasmid pAT780 |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
post-transcriptional methylation of N7-G1405 in 16S rRNA of 30S ribosomal subunits |
Escherichia coli |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus |
Proteus mirabilis |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
RmtC has an MTase activity specific for the bacterial 30S ribosomal subunit consisting of 16S rRNA and several ribosomal proteins, but not for the naked 16S rRNA |
Proteus mirabilis |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the ArmA methylation reaction is specific for the 30S ribosomal subunit. Neither 16S rRNA alone nor the 70S ribosome is a substrate for this reaction under experimental conditions, implicating ribosomal proteins in substrate recognition |
plasmid pAT780 |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins |
Frankia sp. CcI3 |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry |
Frankia sp. CcI3 |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus |
Proteus mirabilis ARS68 |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
RmtC has an MTase activity specific for the bacterial 30S ribosomal subunit consisting of 16S rRNA and several ribosomal proteins, but not for the naked 16S rRNA |
Proteus mirabilis ARS68 |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |