EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
- |
Micromonospora zionensis |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
- |
plasmid pIP1206 |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme confers resistance to aminoglycosides like gentamicin and sisomicin by specifically methylating G1405 in bacterial 16S rRNA |
Micromonospora zionensis |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides |
Micromonospora zionensis |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme gives resistance to kanamycin plus gentamicin by converting residue C-1405 to 7-methylguanosine |
Micromonospora echinospora |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins |
Micromonospora echinospora |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins |
Frankia sp. |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins |
Micromonospora zionensis |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry |
Micromonospora echinospora |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA |
methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry |
Frankia sp. |
S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA |
- |
? |