EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
RNA editing, posttranscriptional process by which uridine residues are added and deleted from mitochondrial mRNAs |
Trypanosoma brucei |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
RNA editing, posttranscriptional RNA processing in which uridylate residues are inserted into and deleted from pre-mRNAs to create start and stop codons, also acts to reseal mRNAs cleaved at incorrect sites |
Trypanosoma brucei |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
RNA editing, unique U insertion and U deletion process, involves cycles of pre-mRNA cleavage, terminal U addition or U removal, and religation, band IV is the RNA editing ligase needed to seal in U deletion |
Trypanosoma brucei |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
RNA-editing |
Tequatrovirus T4 |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
the enzyme is essential for survival of both insect and bloodstream forms of the parasite |
Trypanosoma brucei |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
DraRnl seals 3'-OH/5'-PO4 RNA nicks in either a duplex RNA or an RNA:DNA hybrid, but it cannot seal 3'-OH/5'-PO4 DNA nicks |
Deinococcus radiodurans |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
neither dATP, GTP, CTP, nor UTP can substitute for ATP. RNA ligation at a 3'-OH/5'-PO4 nick in a double-stranded RNA or an RNA-DNA hybrid |
Tequatrovirus T4 |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
the TS2126 RNA ligase catalyzes both inter- and intra-molecular single-stranded DNA ligation to more than 50% completion in not more than a few hours at an elevated temperature, although favoring intramolecular ligation on RNA and single-stranded DNA substrates |
Phage TS2126 |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
the L1 ligase is regioselective for formation of the biologically relevant 5' to 3' phosphodiester bond rather than a 5' to 2' bond |
Enterobacteria phage L1 |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |
6.5.1.3 | ATP + (ribonucleotide)n + (ribonucleotide)m |
Trl1 executes the end-healing and end-sealing steps of tRNA splicing, requires a 2'-PO4 end for tRNA splicing in vivo |
Saccharomyces cerevisiae |
AMP + diphosphate + (ribonucleotide)n+m |
- |
? |