EC Number   |
Substrates |
Products |
Reversibility  |
|---|
   3.4.22.64 | gasdermin D + H2O |
cleavage of gasdermin D (GSDMD) into pore-forming peptides |
? |
- |
? |
| 3.4.22.64 | gasdermin D + H2O |
- |
gasdermin fragment p30 + gasdermin fragment p20 |
- |
? |
| 3.4.22.64 | gasdermin D + H2O |
- |
N-terminal domain of gasdermin D + C-terminal domain of gasdermin D |
- |
? |
| 3.4.22.64 | gasdermin-D + H2O |
- |
? |
- |
? |
| 3.4.22.64 | human interleukin-18 + H2O |
- |
? |
- |
? |
| 3.4.22.64 | more |
optimal cleavage site is IEHD, LEHD, VEHD or PEHD |
? |
- |
? |
| 3.4.22.64 | more |
- |
? |
- |
? |
| 3.4.22.64 | more |
overexpression induces apoptosis |
? |
- |
? |
| 3.4.22.64 | more |
phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock |
? |
- |
? |
| 3.4.22.64 | more |
the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS |
? |
- |
? |
