EC Number   |
Substrates |
Products |
Reversibility |
|---|
   3.4.22.64 | more |
enzyme is involved in cytokine activation |
? |
- |
? |
| 3.4.22.64 | more |
Flightless-I regulates the subcellular distribution of caspase-11 by promoting its localization at the cell leading edge |
? |
- |
? |
| 3.4.22.64 | cationic channel subunit transient receptor potential channel 1 + H2O |
i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses |
? |
- |
? |
| 3.4.22.64 | mouse interleukin-18 + H2O |
low activity |
? |
- |
? |
| 3.4.22.64 | more |
mouse caspase-11 cannot cleave IL-1beta efficiently |
? |
- |
- |
| 3.4.22.64 | more |
mouse caspase-11 has an inadequate capacity to cleave pro-IL-1beta. It cleaves gasdermin D more efficiently than pro-IL-1beta |
? |
- |
- |
| 3.4.22.64 | more |
neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice |
? |
- |
? |
| 3.4.22.64 | more |
neurotoxicity of 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine may be mediated via activation of the caspase-11 cascade and inflammatory cascade, as well as the mitochondrial apoptotic cascade |
? |
- |
? |
| 3.4.22.64 | more |
optimal cleavage site is IEHD, LEHD, VEHD or PEHD |
? |
- |
? |
| 3.4.22.64 | more |
other caspases are substrates of caspase-11 |
? |
- |
? |
