EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.7 | more |
steroid-treated ovariectomized mice deficient in tissue inhibitor of metalloprotease-1 and exposed to estrogen show a significant increase in plasmin activity. Increase is probably due to reduced expression of plasmin inhibitors serpinb7 and serpinb2 |
Mus musculus |
? |
- |
? |
| 3.4.21.7 | annexin A2 + H2O |
stimulation of macrophages with plasmin leads to cleavage of ca. 6% of annexin A2 yielding a proteolytic fragment of ca. 33 kDa |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | more |
subsite interactions of plasmin with substrates and inhibitors through computational docking analysis using the structure with PDB ID 1BML for plasmin in complex with streptokinase and no ligand molecules, molecular dynamic simulation of plasmin, overview. D/L-Ile-Phe-Lys substrate-binding modes |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | more |
substrate competition with urokinase-type plasminogen activator and bistability, overview |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | Fibrin + H2O |
the activation of plasminogen in blood plasma is the central event that results in the dissolution of the fibrin clot by proteolysis |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | C1 inhibitor + H2O |
the C1-inhibitor in its native state inhibits plasmin without significant degradation. If the C1-inhibitor is in a denatured polymeric state as can easily occur during storage, or as produced by heating of the native protein, it will be extensively degraded by plasmin |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | von Willebrand factor + H2O |
the enzyme cleaves von Willebrand factor at K1491-R149. Globular von Willebrand factor is resistant to plasmin cleavage under static conditions, but is readily cleaved by plasmin under shear |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | complement component C3b + H2O |
the enzyme inactivates the C3b molecule for complement C3b amplification |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | Fibrinogen + H2O |
the fibrinogen alpha-chain is degraded in low-molecular-mass fragments of approximately 63000-60000 Da |
Homo sapiens |
? |
- |
? |
| 3.4.21.7 | amyloid-beta + H2O |
the plasmin pathway is induced by aggregated amyloid-beta, which can lead to amyloid-beta degradation and inhibition of amyloid-beta actions |
Homo sapiens |
? |
- |
? |
