EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
   3.3.2.9 | more |
mEH prefers mono- and cis-substituted epoxides, low but highly enantioselective activity with epoxy fatty acids, the enzyme acts as an antiestrogen binding site subunit |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | more |
no activity with 5,6alpha-epoxy-5alpha-cholestan-3beta-ol and 5,6beta-epoxy-5alpha-cholestan-3beta-ol |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | more |
substrate specificity, no activity with 1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene,i.e. HEOM, 2-acetylaminofluorene, arochlor 1254, and benzopyrene 4,5-oxide, the cytosolic enzyme hydrates epoxides on cyclic sytems very slowly, but hydrates a wide variety of aliphatic epoxides rapidly, trisubstituted terpenoid epoxides show low Km-values, fatty acid and ester epoxides are hydrated very quickly |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | more |
the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.11, which specifically utilizes 5,6alpha-epoxy-5alpha-cholestan-3beta-ol, that is no substrate for EC 3.3.2.9 |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | more |
the enzyme shows a broad substrate specificity, all epoxides with a trisubstituted oxirane ring are no or poor substrates, no activity with 5,6alpha-epoxy-5alpha-cholestan-3beta-ol |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | more |
wide substrate specificity, the enzyme prefers mono- and cis-1,2-disubstituted epoxides as substrates, while gem-di-, trans-di-, tri- and tetra-substituted epoxides are either low turnover substrates or inhibitors |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | more |
not active with trans-1,3-diphenylpropene oxide |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | more |
microsomal epoxide hydrolase (mEH) has wide a substrate specificity |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | naphthalene-1,2-oxide + H2O |
- |
Rattus norvegicus |
? |
- |
? |
| 3.3.2.9 | octene 1,2-oxide + H2O |
- |
Rattus norvegicus |
? |
- |
? |
