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<< < Results 11 - 20 of 338 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
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the enzyme may play a significant role in the secondary metabolism of juvenile hormone acid generated by juvenile hormone esterase
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the enzyme plays an important role in the metabolism of various xenobiotic compounds including the polycyclic aromatic hydrocarbon carcinogens. It is specifically involved in the formation of the ultimate carcinogen of benzopyrene
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induced about threefold by 5 mM phenobarbital
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involved in the biotransformation of epoxides produced from either xeno- or endobiotics. The diols produced are generally detoxification products but in several instances, such as 9,10-epoxybenzopyrene-7,8-diol, they are very potent mutagens and possible carcinogens. The enzyme is induced by phenobarbital
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the enzyme is expected to play a purely protective role with respect to epoxides metabolically produced from pharmaceutical drugs
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role in benzopyrene-induced mutagenesis and carcinogenesis
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enzyme is involved in the metabolism of steroids, the microsomal enzyme plays a central role in both the inactivation of primary mutagenic and carcinogenic metabolites of polycyclic aromatic hydrocarbons, and in activating these metabolites to even more toxic or mutagenic secondary products, enzyme production is induced by 3-methylcholanthrene, phenobarbital, trans-stilbene oxide, 2(3)-tert-butyl-4-hydroxyanisol or 2-acetylaminofluorene
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potent and selective induction by trans-stilbene oxide
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probably represents an important factor in the control of reactive epoxides
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the enzyme in Drosophila melanogaster is involved in xenobiotic biotransformation, but not in juvenile hormone metabolism
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<< < Results 11 - 20 of 338 > >>