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<< < Results 81 - 89 of 89
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
leukotriene A4 + H2O
-
(5S,6S)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid
i.e. DHETE
?
leukotriene A4 + H2O
-
(5S,6S)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid + leukotriene B4 + (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic acid
when large amounts of enzyme are incubated with leukotriene A4: 72% (5S,6S)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid, 18% leukotriene B4 and 10% (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic acid
?
L-alanine-4-nitroanilide + H2O
-
L-alanine + 4-nitroaniline
-
?
leukotriene A4 + H2O
-
leukotriene B4
-
?
leukotriene A4 + H2O
model for the binding of leukotriene A4 to the active site
leukotriene B4
-
?
leukotriene A4 + H2O
-
leukotriene B4 + (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic acid
90% leukotriene B4 and 10% (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic acid
?
leukotriene A4 + H2O
-
leukotriene B4 + 5(S),12R-dihydroxy-6,10-trans-8,14-ciseicosatetraenoic acid
product ratio 9:1
?
more
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?
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