EC Number   |
Substrates  |
Products |
Reversibility |
|---|
   3.1.3.56 | more |
enzyme only binds soluble inositol polyphosphates |
? |
- |
? |
| 3.1.3.56 | more |
isofom SHIP2 is unable to dephosphorylate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
? |
- |
? |
| 3.1.3.56 | more |
the enzyme shows high activity and exquisite specificity for the 5-diphosphate group of inositol diphosphates (5-PP-InsP), substrate-binding pocket structure analysis, overview. No activity with inositol hexakisphosphate, poor activity with 2-diphosphoinositol 1,3,4,5,6-pentakisphosphate and 3-diphosphoinositol 1,2,4,5,6-pentakisphosphate. Enzyme Siw14 also acts as protein tyrosine phosphatase, EC 3.1.3.48 |
? |
- |
? |
| 3.1.3.56 | inositol 4,5-bisphosphate + H2O |
- |
inositol 4-phosphate + phosphate |
- |
? |
| 3.1.3.56 | inositol 1,2-cyclic 4,5-trisphosphate + H2O |
poor substrate |
? |
- |
? |
| 3.1.3.56 | glycerophosphoinositol 4,5-bisphosphate + H2O |
at 13% of the rate of inositol 1,4,5-trisphosphate hydrolysis |
glycerophosphoinositol 4-phosphate + phosphate |
- |
? |
| 3.1.3.56 | D-myo-inositol 1,4,5-trisphosphate + H2O |
- |
D-myo-inositol 1,4-bisphosphate + phosphate |
- |
? |
| 3.1.3.56 | D-myo-inositol 1,4,5-trisphosphate + H2O |
involved in regulation of excitation-contraction coupling in skeletal muscle |
D-myo-inositol 1,4-bisphosphate + phosphate |
- |
? |
| 3.1.3.56 | D-myo-inositol 1,4,5-trisphosphate + H2O |
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate |
D-myo-inositol 1,4-bisphosphate + phosphate |
- |
? |
| 3.1.3.56 | D-myo-inositol 1,4,5-trisphosphate + H2O |
- |
myo-inositol 1,4-bisphosphate + phosphate |
- |
? |
