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<< < Results 131 - 140 of 142 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
more
the enzyme activity is included in a complex formed of the scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, and the Ikkalpha and IKKbeta kinases, overview
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more
IKKalpha and IKKbeta are distinctly involved in ERK1-dependent, but IkappaBalpha-P65- and p100-p52-independent, upregulation of MUC5AC mucin transcription in case of infection by Streptococcus pneumoniae, MUC5AC mucin induction also requires pneumolysin and TLR4-dependent MyD88-IRAK1-TRAF6 signaling, molecular mechanism, overview
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more
activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection
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ATP + a protein
autophosphorylation at both Ser and Thr
ADP + a phosphoprotein
-
?
ATP + a protein
the expression of pkn1 is developmentally regulated to start immediately before spore formation. The enzyme plays an important role in the onset of proper differentiation
ADP + a phosphoprotein
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ATP + IkappaBalpha
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ADP + phosphorylated-IkappaBalpha
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ATP + [IkappaB protein]
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ADP + [IkappaB phosphoprotein]
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more
the IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories, IKKalpha is involved in the regulation of histone H3 phosphorylation and acetylation at specific gene promoters in hippocampus in the NF-kappaB pathway, inhibition of IKKalpha regulation results in impairments in fear memory reconsolidation, mechanism, overview
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ATP + [GST-IkappaBalpha1-54 protein]
recombinant substrate derived from mouse IkappaBalpha
ADP + [GST-IkappaBalpha1-54 phosphoprotein]
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ATP + [IkappaB protein]
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ADP + [IkappaB phosphoprotein]
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<< < Results 131 - 140 of 142 > >>