EC Number |
Substrates |
Organism |
Products |
Reversibility |
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2.7.11.10 | more |
IKKalpha enhances p73-mediated transactivation and pro-apoptotic functions in p53-deficient H1299 cells, stabilization of p73, but not of the antagonist p53, by nuclear IKKalpha mediates cisplatin-induced apoptosis, DNA damage-induced accumulation of both p53 and p73alpha is associated with the up-regulation of IKK-alpha and IKK-gamma, a functional interaction might exist between them in DNA damage-mediated apoptotic pathways |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
IKKalpha is involved in the noncanonical NF-kappaB activation pathway, and plays an essential role in thymic organogenesis required for the establishment of self-tolerance, overview |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
IKKalpha is not only a regulator of mammary epithelial proliferation, but is also an important contributor to ErbB2-induced oncogenesis, providing signals that maintain mammary tumor-initiating cells, IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, and is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells, overview |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
IKKbeta subunit of IKK complex is essential for the activation of NF-kappaB in response to various proinflammatory signals, Cys179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines, overview |
Homo sapiens |
? |
- |
? |
2.7.11.10 | more |
IKKepsilon is important in the regulation of the alternative NF-kappaB activation pathway involving p52 and p65, IKKepsilon interacts with p52 and promotes transactivation via p65 |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
IKKepsilon, i.e. IKKi, is implicated in virus induction of interferon-beta, IFNbeta, and development of immunity, IKKepsilon functions in a redundant role to its ubiquitous counterpart, TBK1, in the activation of IRF3 and IRF7 ex vivo, IKKe determines ISGF3 binding specificity, regulaiton, overview |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
mechanisms/pathways of activation and derepression of the IKK complex, regulation, detailed overview |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
the IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories, IKKalpha is involved in the regulation of histone H3 phosphorylation and acetylation at specific gene promoters in hippocampus in the NF-kappaB pathway, inhibition of IKKalpha regulation results in impairments in fear memory reconsolidation, mechanism, overview |
Rattus norvegicus |
? |
- |
? |
2.7.11.10 | more |
IKKalpha interacts with p73 |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
interaction analysis of IKKepsilon with NF-kappaB complex components/p25/p65 by immunoprecipitation and mass spectrometric analysis, overview |
Mus musculus |
? |
- |
? |