EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.10 | ATP + [RelA/p65 protein] |
phosphorylation on Ser536 of the transactivation domain, dependent on lipopolysaccharide-induction, but not on Akt or p65 |
Mus musculus |
ADP + [RelA/p65 phosphoprotein] |
- |
? |
2.7.11.10 | ATP + IkappaBalpha |
recombinant GST-fusion substrate |
Homo sapiens |
ADP + phosphorylated IkappaBalpha |
- |
? |
2.7.11.10 | ATP + [GST-IkappaBalpha1-54 protein] |
recombinant substrate derived from mouse IkappaBalpha |
Toxoplasma gondii |
ADP + [GST-IkappaBalpha1-54 phosphoprotein] |
- |
? |
2.7.11.10 | ATP + [IkappaB protein] |
required for activation of NF-kappaB resulting in activation of signalling pathways |
Mus musculus |
ADP + [IkappaB phosphoprotein] |
- |
? |
2.7.11.10 | ATP + protein p100 |
required for the interaction with the NF-kappaB complex |
Mus musculus |
ADP + phosphorylated protein p100 |
- |
? |
2.7.11.10 | ATP + protein p165 |
required for the interaction with the NF-kappaB complex |
Mus musculus |
ADP + phosphorylated protein p165 |
- |
? |
2.7.11.10 | ATP + [IkappaB protein] |
signalling step of IKK bound to NFkappaB for subsequent ubiquitination of IkappaB and proteolytic degradation |
Homo sapiens |
ADP + [IkappaB phosphoprotein] |
- |
? |
2.7.11.10 | more |
subunit IKKbeta controls the activation of NF-kappaB, important in inflammation, IKKalpha plays a role in lyphoid organogenesis and suppresses NF-kappaB activity by accelerating both the turnover of the NFkappaB subunits RelA and c-Rel, and their removal from pro-inflammatory gene promoters, inactivation of IKKalpha enhances inflammation and bacterial clearance in mice, overview |
Mus musculus |
? |
- |
? |
2.7.11.10 | more |
the enzyme activity is included in a complex formed of the scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, and the Ikkalpha and IKKbeta kinases, overview |
Mus musculus |
? |
- |
? |
2.7.11.10 | ATP + [IkappaB protein] |
the enzyme is also active with a peptide derived from IkappaB protein spanning Ser32 and Ser36 which are phosphorylated |
Homo sapiens |
ADP + [IkappaB phosphoprotein] |
- |
? |