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<< < Results 11 - 20 of 142 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
ATP + Bcl
phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl
ADP + phosphorylated Bcl
-
?
ATP + Bcl
phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl
ADP + phosphorylated Bcl
-
?
ATP + Bcl
Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl
ADP + phosphorylated Bcl10
-
?
ATP + Bcl10
negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview
ADP + phosphorylated Bcl10
-
?
ATP + GST-IkappaBalpha
activity assay
ADP + GST-IkappaBalpha phosphoprotein
-
?
ATP + IkappaB alpha
-
ADP + phosphorylated IkappaB alpha
-
?
ATP + IkappaB protein
the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages
ADP + phosphorylated IkappaB
-
?
ATP + IkappaB protein
-
ADP + IkappaB phosphoprotein
-
?
ATP + IkappaBalpha
-
ADP + phosphorylated IkappaBalpha
-
?
ATP + IkappaBalpha
a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer
ADP + phosphorylated IkappaBalpha
-
?
<< < Results 11 - 20 of 142 > >>