EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.10.2 | ATP + poly-(Tyr-Glu) |
tyrosine kinase substrate, phosphoryated by Swe1p, Mps1p, Ime2p, and Hrr25p, but not by Ste7p, Rad53p, or Mck1p |
Saccharomyces cerevisiae |
ADP + phospho-poly-(Tyr-Glu) |
- |
? |
| 2.7.10.2 | more |
tyrosine kinases play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been shown to mediate malignant cell transformation, Brk may play a key role in lymphomagenesis |
Homo sapiens |
? |
- |
? |
| 2.7.10.2 | ATP + p34cdc2 |
Wee1 kinase inhibits mitosis by directly phosphorylating p34cdc2 on Y15 |
Homo sapiens |
ADP + phosphorylated p34cdc2 |
- |
? |
| 2.7.10.2 | ATP + cyclin-associated cyclin-dependent kinase |
Wee1 negatively regulates cyclin-dependent kinases by phosphorylation on Y15 |
Homo sapiens |
ADP + phosphorylated cyclin-associated cyclin-dependent kinase |
- |
? |
| 2.7.10.2 | more |
Wee1: substrate specificity |
eukaryota |
? |
- |
? |
| 2.7.10.2 | ATP + Src |
wild-type Src and catalytically inactive mutant Src K295M, terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site, Glu510 of Src interacts with Arg283 of Csk in Csk-Src recognition, activity with Src fragments, overview |
Homo sapiens |
ADP + phospho-L-tyrosinyl Src family kinase |
- |
? |
| 2.7.10.2 | ATP + NaV1.2 channel |
Y66 and Y1893, which are in consensus sequences appropriate for binding to the Fyn SH2 domain after phosphorylation, are both required for optimal binding and regulation by Fyn. Y730, which is located near the SH3-binding motif in LI-II, and Y1497 and Y1498 in the inactivation gate in LIII-IV, are also required for optimal regulation, but phosphorylation of these sites likely promotes fast inactivation |
Homo sapiens |
ADP + phospho-L-tyrosinyl-NaV1.2 channel |
- |
? |
| 2.7.10.2 | ATP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G |
Y7 Sox-based substrate, kinetic assay |
Homo sapiens |
ADP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G phosphate |
- |
? |
| 2.7.10.2 | more |
yes gene product is likely to play an important role in oogenesis or early development |
Xenopus laevis |
? |
- |
? |
| 2.7.10.2 | more |
Yes kinase is required during development, overview |
Danio rerio |
? |
- |
? |
