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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
2,3-dihydrodipicolinate + NAD(P)H
-
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?
2,3-dihydrodipicolinate + NAD(P)H
-
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?
2,3-dihydrodipicolinate + NAD(P)H
-
2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?
2,3-dihydrodipicolinate + reduced 3-acetylpyridine adenine dinucleotide
-
2,3,4,5-tetrahydrodipicolinate + oxidized 3-acetylpyridine adenine dinucleotide
-
?
dihydrodipicolinate + NADH + H+
substrate dihydrodipicolinate is instable
tetrahydrodipicolinate + NAD+
-
?
more
DHDPR accepts (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid as true substrate rather than dihydrodipicolinate, suggesting that DHDPR catalyzes an overall deoxygenation reaction, likely by a dehydratase-reductase route, substrate specificity, overview. A critical role is played by residue His 159 in the catalytic mechanism of DHDPR. Replacement of this residue with an alanine or a glutamine is reported to result in a 150-200fold reduction in catalytic rate as well as a 6fold increase in KM. His 159 has been proposed to act as a general acid during catalysis, providing the proton required after hydride addition. No activity with beta-hydroxypyruvate and 3-fluoropyruvate
?
-
-
pyridine dicarboxylate + NADH + H+
stable substrate analog, 25 mM phosphate D2O (deuterium water) buffer, pH 7.8 for NMR analysis of binding interactions with saturation transfer difference titration studies at 298 K (25°C)
reduced pyridine dicarboxylate + NAD+
-
?
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