EC Number   |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Reference |
|---|
   1.3.1.124 | -999 |
- |
analysis of liver fatty acids after the mice are fasted for 24 h indicates that fasting has a minor effect on the lipid content of wild type liver, with an overall increase of 29% in the concentration of fatty acids, in Decr-/- mice, the overall concentration of fatty acids increases by 108% after fasting |
700872 |
| 1.3.1.124 | -999 |
- |
Decr-/- mice show decreased blood glucose and elevated non-esterified fatty acids concentrations after fasting in comparison to wild type mice |
700872 |
| 1.3.1.124 | -999 |
- |
fasting increases the total concentration of acylcarnitines by 2fold in wild type mice (567 nM), in Decr-/- mice, a markedly higher 9fold increase is observed (2150 nM) |
700872 |
| 1.3.1.124 | -999 |
- |
immunoblotting of mitochondrial extracts from liver, muscle and heart with an antibody against human DECR reveals a detectable signal from wild type mice, whereas no signal can be detected for homozygous null mutant mice |
700872 |
| 1.3.1.124 | -999 |
- |
in Decr-/- mice, the overall concentration of fatty acids increases by 108% after fasting, the most profound changes between fasted wild type and Decr-/- mice are observed for the levels of palmitoleic acid (C16:1), oleic acid, linolenic acid (C18:3) and linoleic acid, which are 2.5- to 3.8fold higher in Decr-/- mice, in comparison to the fed state, the concentrations of monounsaturated fatty acids and polyunsaturated fatty acids increase by 288% and 254%, respectively |
700872 |
| 1.3.1.124 | -999 |
- |
mitochondrial 2,4-dienoyl-CoA reductase activity in mice is indispensable for the complete oxidation of (poly)unsaturated fatty acids and for adaptation to metabolic stress |
700872 |
| 1.3.1.124 | -999 |
- |
mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis |
700872 |
| 1.3.1.124 | 0.00281 |
- |
4-cis-decenoyl-CoA, NADPH, protein fraction virtually free of 2-enoyl-CoA reductase activity |
390712 |
| 1.3.1.124 | 0.003 |
- |
2-trans,4-trans-decadienoyl-CoA, NADPH, muscle |
390717 |
| 1.3.1.124 | 0.0046 |
- |
2-trans,4-cis-decadienoyl-CoA, NADPH, muscle |
390717 |
