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Results 1 - 8 of 8
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Reference
-999
-
ability of human properdin to restore LPS-dependent AP complement activity in properdin-deficient mouse serum shown to be correlated with the human properdin-binding affinity of the LPS
-999
-
central role of the amplification loop in complement activation discussed, development of a model placing the amplification loop at the center of the complement system as a means to expand complement component C3/C5 activation and irrespective of the origin of the triggering complement component C3b molecules
-999
-
complement component C3 cleavage through the mannan-binding lectin (MBL) pathway in mouse sera determined, experimental conditions described
-999
-
convertase formation and activity shown, Western blot, ELISA and fluorescence resonance energy transfer (FRET) used to study formation of the fluid-phase AP convertases C3(H2O)Bb and C3bBb, regulation by factor H and factor I determined, higher affinity for complement component C3(H2O) than for complement component C3b determined, convertase activity of C3bBb higher than of C3(H2O)Bb, C3(H2O)Bb convertase more resistant to inactivation by factor H and factor I than the C3bBb convertase, 25% of initial activity of complement component C3(H2O)Bb retained at conditions that totally inactivate C3bBb
-999
-
deposition of the solid-phase activation product complement component C3b on a mannan-coated surface at a high concentration of 17% of human serum determined, function of the proteases MASP-1 and MASP-2 in the generation of complement component C3 convertase at high but not at low serum concentrations
-999
-
hemolysis assay to assess inhibition by DAF mutants described, equilibrium analysis of recombinant soluble DAF mutants binding to complement component C3b shown, kinetic constants for binding of DAF mutants to the complement component C3b and fragment Bb and ability to decay AP convertase determined, interaction of DAF with properdin and decay of properdin-stabilized convertase indicated, binding kinetics of fragment Bb to recombinant soluble DAF mutants DAF1234, DAF23 and DAF34 determined, decay of AP C3 convertase by DAF and DAF mutants monitored
-999
-
LPS- and LOS-induced AP complement activation abolished in properdin-deficient mouse serum, zymosan- and cobra venom factor-induced AP complement activation observed, classical pathway-triggered AP complement amplification only partially or minimally affected in properdin-deficient mice, ability of human properdin to restore LPS-dependent AP complement activity in properdin-deficient mouse serum shown to be correlated with the human properdin-binding affinity of the LPS
-999
-
plasma levels of complement components determined in patients with severe trauma
Results 1 - 8 of 8