EC Number   |
Source Tissue |
Reference |
|---|
   3.4.17.21 | 22Rv1 cell |
- |
708256 |
| 3.4.17.21 | astrocyte |
- |
669923, 669962, 670363, 670397, 701258, 731257, 752980 |
| 3.4.17.21 | astrocyte |
the level of glutamate carboxypeptidase II protein (GCPII) is regulated by valproic acid, a histone deacetylase (HDAC) inhibitor, through acetylation of lysine residue in the GCPII protein in human astrocytes, U-87MG |
752648 |
| 3.4.17.21 | blood |
- |
697394 |
| 3.4.17.21 | blood plasma |
the enzyme is present in human blood, and its concentration within a healthy population varies between 1.3 and 17.2 ng/ml |
755286 |
| 3.4.17.21 | brain |
- |
-, 137210, 137217, 137221, 137222, 137223, 137224, 137225, 655290, 656468, 667114, 668408, 669943, 669962, 670363, 670857, 696330, 701206, 701258, 707124, 709605 |
| 3.4.17.21 | brain |
amygdala, caudate-putamen, central gray, dorsal raphe, globus pallidus, hippocampus, hypothalamus, locus coerulus, medial and lateral geniculate, olfactory bulb, periaqueductal gray, solitary nucleus, spinal trigeminal nucleus, substantia nigra, superior colliculus, thalamus, corpus callosum, fornix, habenular commissure, solitary tract, stria medularis, stria therminalis |
137229 |
| 3.4.17.21 | brain |
considerably increased in prostate carcinoma |
753584 |
| 3.4.17.21 | brain |
decreased gene expression and activity in the frontal and temporal lobe, the dorsolateral prefrontal cortex, and the hippocampus in schizophrenia, overview, no intracellular activity in pyramidal cells and their dendrites |
670397 |
| 3.4.17.21 | brain |
especially midbrain and cerebellum, quantitative detection of GCPII content in the brain by labeling with [125I]-N-[N-((S)-1,3-dicarboxypropyl)carbamoyl]-S-3-iodo-L-tyrosine is a potent antagonist of the enzyme activity |
670406 |
