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EC Number Source Tissue Commentary Reference
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5adipose tissue - 742856
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5aortic endothelial cell - 757773
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5ascites tumor cell - 701402
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5brain - 725456
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5brain high expression level 742856
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5carcinoma cell highly expressed in many cancer types 756334
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5cotyledon - 1518, 209737, 392326
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5embryo both Mthfd2 and Mthfd2l are expressed during embryogenesis but differ in timing of expression. Mthfd2l expression is low in early developmental stages but begins to increase at embryonic day 10.5 and remains elevated through birth while Mthfd2 is expressed more abundantly during early developmental stages and begins to taper off, with little or no expression observed in most adult tissues 756334
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5embryo enzyme MTHFD2L is expressed in embryonic tissues during neural tube closure. Expression of the MTHFD2L transcript is low in early mouse embryos but begins to increase at embryonic day 10.5 and remains elevated through birth, in situ hybridization of whole mouse embryos -, 742856
Show all pathways known for 1.5.1.5Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.5head and neck squamous cell carcinoma cell HNSCC cell carcinoma, a total of 121 significantly altered IRMEs are identified between HNSCC and normal tissues, and 21 IRMEs are found to be strongly associated with overall survival of HNSCC. THe expression level of MTHFD1 is significantly overexpressed in tumor tissues compared to the normal controls in both GSE6631 and TCGA HNSCC cohort 764552
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