EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
ovary cancer cell |
- |
725814 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
ovary cancer cell |
- |
740542 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
ovary cancer cell |
- |
756531 |
1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase |
ovary cancer cell |
ovarian carcinoma, GI-102 |
675897 |
1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) |
ovary cancer cell |
- |
689367 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
ovary cancer cell |
- |
742556 |
1.8.1.9 | thioredoxin-disulfide reductase |
ovary cancer cell |
inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells |
686863 |
2.1.1.360 | [histone H3]-lysine79 N-trimethyltransferase |
ovary cancer cell |
- |
754850 |
2.2.1.1 | transketolase |
ovary cancer cell |
- |
756500 |
2.3.1.48 | histone acetyltransferase |
ovary cancer cell |
- |
703846, 756850 |
2.3.1.50 | serine C-palmitoyltransferase |
ovary cancer cell |
strong overexpression of both SPT subunits |
659621 |
2.3.1.57 | diamine N-acetyltransferase |
ovary cancer cell |
C13 |
672937 |
2.3.1.85 | fatty-acid synthase system |
ovary cancer cell |
- |
673222 |
2.3.1.85 | fatty-acid synthase system |
ovary cancer cell |
positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells |
676254 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
ovary cancer cell |
GnT-III expression significantly increases ovarian cancer growth and metastasis and increases the expansion of the ovarian cancer stem cell (CSC) population |
759483 |
2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
ovary cancer cell |
EOC, GCNT3 expression is analyzed in a cohort of 56 EOC patients followed by a meta-analysis of more than one thousand patients |
760171 |
2.4.1.212 | hyaluronan synthase |
ovary cancer cell |
- |
692996 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
ovary cancer cell |
- |
703916 |
2.4.2.4 | thymidine phosphorylase |
ovary cancer cell |
tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control |
658872 |
2.4.3.6 | N-acetyllactosaminide alpha-2,3-sialyltransferase |
ovary cancer cell |
- |
758725 |
2.5.1.60 | protein geranylgeranyltransferase type II |
ovary cancer cell |
significant overexpression of RabGGT-beta and RabGGT-alpha compared to normal tissue |
658377 |
2.7.1.105 | 6-phosphofructo-2-kinase |
ovary cancer cell |
- |
760902 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
ovary cancer cell |
- |
710173 |
2.7.10.1 | receptor protein-tyrosine kinase |
ovary cancer cell |
EGF-R is moderately present in serous and mucinous borderline tumors and increases in adenocarcinomas, whereas TGF-alpha is moderately present |
690295 |
2.7.10.1 | receptor protein-tyrosine kinase |
ovary cancer cell |
Ron and Met are significantly coexpressed. Also another short form Ron is present |
690303 |
2.7.12.2 | mitogen-activated protein kinase kinase |
ovary cancer cell |
impaired expression of MKK4 |
682214 |
2.7.12.2 | mitogen-activated protein kinase kinase |
ovary cancer cell |
weak expression |
677913 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
ovary cancer cell |
- |
660992 |
2.7.7.49 | RNA-directed DNA polymerase |
ovary cancer cell |
- |
692539 |
2.8.3.5 | 3-oxoacid CoA-transferase |
ovary cancer cell |
- |
762068 |
3.1.3.4 | phosphatidate phosphatase |
ovary cancer cell |
- |
709420 |
3.1.3.4 | phosphatidate phosphatase |
ovary cancer cell |
shows reduced LPP1 activity |
663994 |
3.1.3.66 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase |
ovary cancer cell |
- |
731696 |
3.1.4.1 | phosphodiesterase I |
ovary cancer cell |
- |
714113 |
3.1.6.2 | steryl-sulfatase |
ovary cancer cell |
- |
716213 |
3.2.1.166 | heparanase |
ovary cancer cell |
- |
731867 |
3.4.11.18 | methionyl aminopeptidase |
ovary cancer cell |
- |
682206 |
3.4.11.2 | membrane alanyl aminopeptidase |
ovary cancer cell |
- |
683301, 683556, 683561, 707970 |
3.4.21.106 | hepsin |
ovary cancer cell |
- |
671835 |
3.4.21.106 | hepsin |
ovary cancer cell |
in ovarian cancer hepsin expression is mainly confined to the epithelial cells and not the adjacent stroma |
698324 |
3.4.21.107 | peptidase Do |
ovary cancer cell |
high HtrA1 expression levels |
683704 |
3.4.21.108 | HtrA2 peptidase |
ovary cancer cell |
benign tumor, borderline tumor, cancer, Krukenberg tumor |
697363 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
ovary cancer cell |
- |
677579, 682553, 683366 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
ovary cancer cell |
KLK7 is upregulated in epithelial ovarian carcinoma, expression of two different KLK7 transcripts, KLK7-253 and KLK7-181, simultaneously |
707990 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
ovary cancer cell |
over-expressed in ovarian carcinoma tissues. Elevated KLK 7 mRNA expression in tumor tissue is associated with poorer prognosis for ovarian cancer patients |
691153 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
ovary cancer cell |
overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells |
664273 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
ovary cancer cell |
quantitative in situ protein expression analysis of 150 advanced-stage ovarian cancer samples of primary epithelial ovarian cancer patients, method development, overview |
677579 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
ovary cancer cell |
short mRNA variant for KLK7 (alternative AUG, predicted protein N-terminally truncated and lacking catalytic histidine residue) expressed in normal ovary and in ovarian cancer |
664272 |
3.4.21.118 | kallikrein 8 |
ovary cancer cell |
epithelial ovarian tumor |
668282, 670447 |
3.4.21.119 | kallikrein 13 |
ovary cancer cell |
- |
667393, 669632 |
3.4.21.35 | tissue kallikrein |
ovary cancer cell |
- |
678522 |
3.4.21.35 | tissue kallikrein |
ovary cancer cell |
KLK4 and KLK11 |
679016 |
3.4.21.75 | Furin |
ovary cancer cell |
- |
708162 |
3.4.21.B10 | neurosin |
ovary cancer cell |
- |
664273, 753300 |
3.4.21.B10 | neurosin |
ovary cancer cell |
gene amplification is one mechanism for the overexpression of hK6 in ovarian cancer. High expression of hK6 protein in coexisting benign, borderline and invasive ovarian tumours is observed. The tumours also express high levels of kallikrein 6 mRNA |
664465 |
3.4.21.B10 | neurosin |
ovary cancer cell |
KLK6 is upregulated |
679036 |
3.4.21.B10 | neurosin |
ovary cancer cell |
KLK6 is upregulated. In benign tumour tissue, KLK6 expression is low |
678956 |
3.4.21.B10 | neurosin |
ovary cancer cell |
the enzyme is up-regulated in ovarian cancer |
731397 |
3.4.21.B12 | prostase |
ovary cancer cell |
- |
664273, 681390 |
3.4.21.B12 | prostase |
ovary cancer cell |
abundance of K4 comparable to that in breast carcinoma, higher expression as compared to malignant mesothelioma |
686322 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
ovary cancer cell |
- |
731043, 731767 |
3.4.21.B39 | stratum corneum tryptic enzyme |
ovary cancer cell |
expression |
670978 |
3.4.21.B39 | stratum corneum tryptic enzyme |
ovary cancer cell |
high expression |
670977 |
3.4.21.B41 | kallikrein 10 |
ovary cancer cell |
- |
682961 |
3.4.21.B41 | kallikrein 10 |
ovary cancer cell |
significantly upregulated |
670979 |
3.4.21.B42 | hippostasin |
ovary cancer cell |
gene expression |
668270 |
3.4.21.B6 | prostasin |
ovary cancer cell |
enzyme levels significantly higher than those in control cells |
673905 |
3.4.22.1 | cathepsin B |
ovary cancer cell |
epithelial, cathepsin B is significantly higher in patients older than compared with patients younger than 57 years of age |
708376 |
3.4.22.34 | Legumain |
ovary cancer cell |
legumain is overexpressed in the majority of human solid tumours, including breast cancer, colorectal cancer, ovarian cancer, prostate cancer and gastric cancer |
752851 |
3.4.23.B1 | napsin |
ovary cancer cell |
the distribution of histotypes for 279 ovarian tumours are analysed |
754994 |
3.4.24.7 | interstitial collagenase |
ovary cancer cell |
ovarian clear cell carcinoma cell |
698145 |
3.4.24.B7 | matrix metalloproteinase-26 |
ovary cancer cell |
no elevated MMP-26 expression level |
710794 |
4.2.1.11 | phosphopyruvate hydratase |
ovary cancer cell |
ENOA is upregulated |
714970 |
4.3.2.9 | gamma-glutamylcyclotransferase |
ovary cancer cell |
- |
705761 |
5.3.99.2 | Prostaglandin-D synthase |
ovary cancer cell |
human ovarian cancer cells. Prostaglandin synthase and testicular factor SOX9 are expressed at both RNA and protein levels in different types of ovarian tumors, while treatment of these cells with prostaglandin D2 can inhibit their growth and induce apoptosis |
679017 |
5.6.2.3 | DNA 5'-3' helicase |
ovary cancer cell |
- |
757877 |
6.3.4.5 | argininosuccinate synthase |
ovary cancer cell |
AS mRNA increases 2- to 3fold by 24 h in both the IGROV-1 cell line, and a second ovarian cancer cell line OVCAR-3, following treatment with TNF-alpha. In contrast, although the ovarian cancer cell lines, PEO1 and SKOV-3, express AS in abundance, this is not TNF-a-inducible |
674048 |
6.3.4.5 | argininosuccinate synthase |
ovary cancer cell |
TNF-alpha induces prolonged expression of AS mRNA and protein in ovarian tumour cells, contrasting with short-lived expression of AS mRNA in the normal ovarian epithelial cells. AS mRNA is higher expressed in ovarian tumor tissue compared to normal ovarian tissue. Moreover, AS protein colocalises with TNF-alpha in ovarian cancer cells, with significantly higher levels of AS in malignant compared with normal ovarian tissue. |
674048 |
6.3.5.4 | asparagine synthase (glutamine-hydrolysing) |
ovary cancer cell |
- |
675914 |