EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
osteoclast |
bone resorbing cells, derive from monocyte/macrophage cell lineage |
759544 |
2.7.1.137 | phosphatidylinositol 3-kinase |
osteoclast |
- |
640914 |
2.7.1.137 | phosphatidylinositol 3-kinase |
osteoclast |
the phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis |
688768 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
osteoclast |
osteoclasts express multiple regulatory subunits of class IA PI3-K, although the expression of the full-length form of p85alpha is most abundant |
709930 |
2.7.10.2 | non-specific protein-tyrosine kinase |
osteoclast |
- |
691661 |
2.7.10.2 | non-specific protein-tyrosine kinase |
osteoclast |
osteoclast lineage cell, preosteoclast |
693038 |
2.7.10.2 | non-specific protein-tyrosine kinase |
osteoclast |
PYK2 |
673223 |
2.7.11.1 | non-specific serine/threonine protein kinase |
osteoclast |
- |
723080 |
2.7.11.1 | non-specific serine/threonine protein kinase |
osteoclast |
cultured on ivory |
491311 |
2.7.11.10 | IkappaB kinase |
osteoclast |
- |
662547 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
osteoclast |
- |
-, 675034 |
2.7.12.1 | dual-specificity kinase |
osteoclast |
- |
761591 |
3.1.3.2 | acid phosphatase |
osteoclast |
- |
134776, 134784, 134785, 652665, 665956, 666100, 679089 |
3.1.3.48 | protein-tyrosine-phosphatase |
osteoclast |
- |
692163, 752091 |
3.1.3.48 | protein-tyrosine-phosphatase |
osteoclast |
cyt-PTPepsilon is expressed strongly in osteoclasts and is virtually absent from osteoblasts, RPTPepsilon is not expressed in either cell type, function of cyt-PTPepsilon is critical for proper organization of podosomes in osteoclasts |
692163 |
3.1.3.48 | protein-tyrosine-phosphatase |
osteoclast |
PTP-oc is expressed quite strongly in osteoclasts and positively regulates osteoclast production and activity |
692163 |
3.1.4.12 | sphingomyelin phosphodiesterase |
osteoclast |
- |
714052 |
3.4.15.1 | peptidyl-dipeptidase A |
osteoclast |
- |
707920 |
3.4.16.5 | carboxypeptidase C |
osteoclast |
a cDNA of bone marrow-derived monocyte/macrophage osteoclast progenitors is used |
699085 |
3.4.21.107 | peptidase Do |
osteoclast |
- |
753322 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
osteoclast |
- |
678961 |
3.4.22.15 | cathepsin L |
osteoclast |
- |
711349 |
3.4.22.38 | cathepsin K |
osteoclast |
- |
-, 30355, 30358, 30361, 30362, 30365, 30366, 30369, 654410, 656456, 656457, 656472, 657251, 696654, 697010, 697012, 697066, 697257, 697775, 698935, 699557, 700549, 700688, 707899, 708260, 708689, 709855, 717159, 717867, 718051, 753907, 753977, 754289, 754497 |
3.4.22.38 | cathepsin K |
osteoclast |
cathepsin K is one of the cysteine proteases expressed by osteoclasts, particularly at the cell surface adjacent to bone |
699971 |
3.4.22.38 | cathepsin K |
osteoclast |
cathepsin K is secreted by osteoclasts, when they are resorbing bone |
701297 |
3.4.22.38 | cathepsin K |
osteoclast |
cathepsin K, colocalizes with tartrate-resistant acid phosphatase in osteoclast-resorptive compartments, supporting a role for cathepsin K in the extracellular processing of monomeric tartrate-resistant acid phosphatase in the resorption lacuna |
669364 |
3.4.22.38 | cathepsin K |
osteoclast |
CatK expressed predominantly in osteoclasts |
697011 |
3.4.22.38 | cathepsin K |
osteoclast |
expressed selectively in the osteoclast |
708572 |
3.4.22.38 | cathepsin K |
osteoclast |
from either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, mice, phenotypes, overview |
695956 |
3.4.22.38 | cathepsin K |
osteoclast |
giant multinucleated cells,high expression level |
696041 |
3.4.22.38 | cathepsin K |
osteoclast |
high activity |
30368 |
3.4.22.38 | cathepsin K |
osteoclast |
localized on the surface of alveolar bone, expression pattern of cathepsin K, no co-expression with matrix metalloproteinase-9 |
695899 |
3.4.22.38 | cathepsin K |
osteoclast |
mature |
696631 |
3.4.22.38 | cathepsin K |
osteoclast |
predominant expression in osteoclasts |
708450 |
3.4.22.38 | cathepsin K |
osteoclast |
strong expression in ankylosing spondylitis patients |
695609 |
3.4.23.34 | cathepsin E |
osteoclast |
- |
677990 |
3.4.24.19 | procollagen C-endopeptidase |
osteoclast |
- |
668838 |
3.4.24.23 | matrilysin |
osteoclast |
- |
707987 |
3.4.24.35 | gelatinase B |
osteoclast |
- |
708393 |
3.4.24.65 | macrophage elastase |
osteoclast |
- |
754996 |
3.4.24.B10 | ADAM12 endopeptidase |
osteoclast |
- |
669565, 680191 |
3.6.5.2 | small monomeric GTPase |
osteoclast |
- |
684840, 735277 |
3.6.5.5 | dynamin GTPase |
osteoclast |
- |
670205 |
4.4.1.1 | cystathionine gamma-lyase |
osteoclast |
- |
747006 |
7.1.2.1 | P-type H+-exporting transporter |
osteoclast |
- |
710812 |
7.1.2.1 | P-type H+-exporting transporter |
osteoclast |
vacuolar H+-ATPase |
712552 |
7.1.2.2 | H+-transporting two-sector ATPase |
osteoclast |
- |
710812 |
7.1.2.2 | H+-transporting two-sector ATPase |
osteoclast |
vacuolar H+-ATPase |
712552 |