EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.14.16.2 | tyrosine 3-monooxygenase |
nucleus accumbens |
primary cell culture |
688523 |
1.4.3.4 | monoamine oxidase |
nucleus accumbens |
- |
705454 |
1.4.3.5 | pyridoxal 5'-phosphate synthase |
nucleus accumbens |
5.2% of the activity in liver |
655483 |
2.5.1.16 | spermidine synthase |
nucleus accumbens |
highest levels of expression in nucleus accumbens, taenia tecta, cerebellar cortex, cerebral cortical layer I, hippocampus, hypothalamus, mesencephalic raphe nuclei, central and lateral amygdala, and the circumventricular organs |
688510 |
2.6.1.19 | 4-aminobutyrate-2-oxoglutarate transaminase |
nucleus accumbens |
- |
759407 |
2.7.1.107 | diacylglycerol kinase (ATP) |
nucleus accumbens |
DGK-II |
640375 |
2.7.1.137 | phosphatidylinositol 3-kinase |
nucleus accumbens |
shell and core. Cocaine sensitization decreases PI3K activity in nuclear accumbens core. The changes are not normalized following the reversal of cocaine-sensitization. Cocaine-sensitized animals exhibited increased PI3K activity in the nuclear accumbens shell, and this increase is reversed by combined pergolide/ondansetron treatment. Selective enhancement of the PI3K activity in the NAc shell may be one of key alterations underlying the long-term cocaine sensitization |
671736 |
3.1.1.7 | acetylcholinesterase |
nucleus accumbens |
- |
729516 |
3.4.11.7 | glutamyl aminopeptidase |
nucleus accumbens |
highest activity |
699650 |
3.4.21.26 | prolyl oligopeptidase |
nucleus accumbens |
Core and Shell |
694399 |
3.4.21.73 | u-Plasminogen activator |
nucleus accumbens |
study on cocaine-induced conditioned-place preference in rats with bilateral intra-accumbens injections of uPA-expressing lentiviral vectors. Overexpression of uPA in the nucleus accumbens significantly augments cocaine-induced place preference. Reinstatement with a low dose of cocaine produces significantly greater preference to the cocaine-associated context. Inhibition of tuPA expression using doxycycline abolishes the augmented acquisition produced by overexpression of uPA but not the expression of the cocaine-induced conditioned-place preference. Cocaine-induced cocaine-induced conditioned-place preference and reinstatement may be dependent on active extracellular uPA |
695974 |
3.6.1.13 | ADP-ribose diphosphatase |
nucleus accumbens |
- |
209946 |
4.1.1.15 | glutamate decarboxylase |
nucleus accumbens |
- |
699831 |