EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
melanoma cell |
- |
760802 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
melanoma cell |
- |
761332 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
melanoma cell |
- |
711107 |
1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) |
melanoma cell |
- |
764226 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
melanoma cell |
- |
713361 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
melanoma cell |
- |
685815 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
melanoma cell |
quantitative HO-1 expression analysis |
687181 |
1.14.15.18 | calcidiol 1-monooxygenase |
melanoma cell |
- |
659811 |
1.14.16.4 | tryptophan 5-monooxygenase |
melanoma cell |
- |
658187 |
1.14.18.1 | tyrosinase |
melanoma cell |
- |
636339, 636340, 636355, 636360, 636374, 636398, 636401, 636402, 636412, 636416, 636417, 636418, 636422, 636425, 636430, 696686, 744671, 746188, 746346 |
1.5.1.3 | dihydrofolate reductase |
melanoma cell |
DHFR is overexpressed in melanoma cells |
705800 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
melanoma cell |
- |
-, 725514, 742841 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
melanoma cell |
- |
742556 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
melanoma cell |
- |
746204 |
1.7.1.7 | GMP reductase |
melanoma cell |
expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de novo biosynthesis of purine nucleotides, is downregulated in invasive stages of human melanoma. From 9 arbitrarily chosen human metastatic melanoma cell lines, GMPR is expressed in only one cell line |
742245 |
1.8.1.9 | thioredoxin-disulfide reductase |
melanoma cell |
amelanotic |
394906 |
1.8.1.9 | thioredoxin-disulfide reductase |
melanoma cell |
metastatic melanotic |
394906, 394908, 394909, 394911 |
2.1.1.366 | [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase |
melanoma cell |
- |
759353 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
melanoma cell |
- |
705661 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
melanoma cell |
diverse cell lines |
715720 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
melanoma cell |
- |
487039 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
melanoma cell |
sialic acid O-acetylation levels in different samples, overview |
677235 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
melanoma cell |
overexpression of SIRT6 in human melanoma tissues |
756871 |
2.3.2.2 | gamma-glutamyltransferase |
melanoma cell |
GGT-overexpression in melanoma cells is associated with resistance to oxidative stress produced by prooxidant agents such as hydrogen peroxide and ascorbic acid |
686496 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
melanoma cell |
- |
759839 |
2.3.3.10 | hydroxymethylglutaryl-CoA synthase |
melanoma cell |
although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells |
757174 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
melanoma cell |
GCNT3 is overexpressed in highly metastatic melanomas |
759882 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
melanoma cell |
- |
688812, 735724, 759316 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
melanoma cell |
- |
735724 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
melanoma cell |
parental mouse melanoma cell S91 6neo |
688812, 693954 |
2.4.1.274 | glucosylceramide beta-1,4-galactosyltransferase |
melanoma cell |
- |
736198 |
2.4.1.80 | ceramide glucosyltransferase |
melanoma cell |
- |
735591 |
2.4.1.90 | N-acetyllactosamine synthase |
melanoma cell |
Bowes melanoma cell line |
658123 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
melanoma cell |
high expression level |
735601 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
melanoma cell |
- |
735872, 760200 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
melanoma cell |
- |
671628 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
melanoma cell |
MTAP expression analysis |
671628 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
melanoma cell |
reduced activity due to hypermethylation of the promotor |
637557 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
melanoma cell |
- |
637260 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
melanoma cell |
- |
735601, 764085, 764812 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
melanoma cell |
- |
736209, 764220 |
2.5.1.60 | protein geranylgeranyltransferase type II |
melanoma cell |
significant overexpression of RabGGT-beta and Rab-GGT-alpha compared to normal tissue |
658377 |
2.7.1.107 | diacylglycerol kinase (ATP) |
melanoma cell |
- |
672420 |
2.7.1.107 | diacylglycerol kinase (ATP) |
melanoma cell |
expression of isoform diacylglycerol kinase alpha in several melanoma cell lines but not in noncancerous melanocytes |
672420 |
2.7.1.147 | ADP-specific glucose/glucosamine kinase |
melanoma cell |
- |
723169 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
melanoma cell |
- |
721967 |
2.7.1.91 | sphingosine kinase |
melanoma cell |
- |
671356, 761980 |
2.7.10.2 | non-specific protein-tyrosine kinase |
melanoma cell |
elevated levels of malignant cells |
490359 |
2.7.11.1 | non-specific serine/threonine protein kinase |
melanoma cell |
- |
662601 |
2.7.11.20 | elongation factor 2 kinase |
melanoma cell |
- |
760309 |
2.7.11.22 | cyclin-dependent kinase |
melanoma cell |
- |
665840 |
2.7.11.26 | tau-protein kinase |
melanoma cell |
- |
740135 |
2.7.12.2 | mitogen-activated protein kinase kinase |
melanoma cell |
- |
740419 |
2.7.12.2 | mitogen-activated protein kinase kinase |
melanoma cell |
choroidal from eyes, and cutaneous |
665489 |
2.7.7.49 | RNA-directed DNA polymerase |
melanoma cell |
- |
692248 |
2.7.7.8 | polyribonucleotide nucleotidyltransferase |
melanoma cell |
- |
672972, 723628 |
2.7.8.27 | sphingomyelin synthase |
melanoma cell |
isozymes SMS1 and SMS2 |
692991 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
melanoma cell |
- |
713731 |
3.1.1.64 | retinoid isomerohydrolase |
melanoma cell |
malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters into 11-cis retinol, whereas melanocytes are not able to catalyze these reactions |
715720 |
3.1.3.16 | protein-serine/threonine phosphatase |
melanoma cell |
- |
708789 |
3.1.3.36 | phosphoinositide 5-phosphatase |
melanoma cell |
- |
730456 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
melanoma cell |
minor splice isozyme PFKFB-4, major isozyme is PFKFB-3 |
666334 |
3.1.3.5 | 5'-nucleotidase |
melanoma cell |
- |
677542 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
melanoma cell |
- |
696397 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
melanoma cell |
secrets the mature ATX |
713665 |
3.2.1.24 | alpha-mannosidase |
melanoma cell |
- |
665978 |
3.2.1.49 | alpha-N-acetylgalactosaminidase |
melanoma cell |
cutaneous melanoma, specific enzymatic activity of serum alpha-N-acetylgalactosaminidase is significantly increased in stage III melanoma patients, but not in early stages |
707963 |
3.2.2.29 | thymine-DNA glycosylase |
melanoma cell |
- |
706938, 751763 |
3.4.11.2 | membrane alanyl aminopeptidase |
melanoma cell |
- |
35865, 664466, 665112 |
3.4.13.9 | Xaa-Pro dipeptidase |
melanoma cell |
high enzyme expression level |
683964 |
3.4.13.9 | Xaa-Pro dipeptidase |
melanoma cell |
high expression level |
707010 |
3.4.13.9 | Xaa-Pro dipeptidase |
melanoma cell |
higher expression of prolidase in tumor cells and particularly in melanoma cells |
683061 |
3.4.14.5 | dipeptidyl-peptidase IV |
melanoma cell |
- |
703784 |
3.4.21.112 | site-1 protease |
melanoma cell |
the enzyme SKI-1 is constitutively expressed in human pigment cells with higher SKI activity in seven out of eight melanoma cell lines compared with normal melanocytes, also detectable in tumor cells of melanoma metastases |
732292 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
melanoma cell |
- |
752892 |
3.4.21.5 | thrombin |
melanoma cell |
- |
717955 |
3.4.21.53 | Endopeptidase La |
melanoma cell |
- |
731618 |
3.4.21.61 | Kexin |
melanoma cell |
- |
732728 |
3.4.21.68 | t-Plasminogen activator |
melanoma cell |
- |
29577, 29592 |
3.4.21.68 | t-Plasminogen activator |
melanoma cell |
cell-conditioned serum-free medium, Bowes |
29587 |
3.4.21.75 | Furin |
melanoma cell |
- |
753199 |
3.4.21.B27 | proprotein convertase 7 |
melanoma cell |
- |
753199 |
3.4.22.1 | cathepsin B |
melanoma cell |
- |
681195, 753138 |
3.4.22.15 | cathepsin L |
melanoma cell |
- |
696091, 712921 |
3.4.22.15 | cathepsin L |
melanoma cell |
cathepsin L activity was detected in the cell culture supernatant by lithium dodecyl sulfate gelatin zymography |
667194 |
3.4.22.36 | caspase-1 |
melanoma cell |
- |
709153 |
3.4.22.38 | cathepsin K |
melanoma cell |
immunostaining reveals strong catK expression in most primary melanomas and all cutaneous melanoma metastases. Melanocytic nevi also demonstrates catK expression, but it is less intense than in melanomas. Melanoma lines express both the pro- and the active form of catK |
681252 |
3.4.22.43 | cathepsin V |
melanoma cell |
- |
752678 |
3.4.22.52 | calpain-1 |
melanoma cell |
- |
709406 |
3.4.22.54 | calpain-3 |
melanoma cell |
- |
708013 |
3.4.22.56 | caspase-3 |
melanoma cell |
- |
700600 |
3.4.22.56 | caspase-3 |
melanoma cell |
expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview |
698197 |
3.4.22.61 | caspase-8 |
melanoma cell |
expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview |
698197 |
3.4.24.16 | neurolysin |
melanoma cell |
- |
-, 754898 |
3.4.24.23 | matrilysin |
melanoma cell |
primary cutaneous and metastatic melanoma |
683312 |
3.4.24.24 | gelatinase A |
melanoma cell |
- |
684054, 752865 |
3.4.24.56 | insulysin |
melanoma cell |
- |
668184 |
3.4.24.7 | interstitial collagenase |
melanoma cell |
of invasive melanomas |
683330 |
3.4.24.7 | interstitial collagenase |
melanoma cell |
VMM5 cells, VMM12cells and VMM39. Constitutive overexpression of collagenase 1 is mediated by the ERK pathway in invasive melanoma cells |
669246 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
melanoma cell |
- |
734297 |