EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.13.11.33 | arachidonate 15-lipoxygenase |
mast cell |
- |
689807 |
1.13.11.33 | arachidonate 15-lipoxygenase |
mast cell |
from lungs of asthma patients, and from skin and cord blood |
685338 |
1.13.11.33 | arachidonate 15-lipoxygenase |
mast cell |
medium expression |
706579 |
1.13.11.34 | arachidonate 5-lipoxygenase |
mast cell |
- |
660111, 671659, 704997, 711100, 743614 |
1.13.11.34 | arachidonate 5-lipoxygenase |
mast cell |
bone marrow-derived mast cell line PB-3c |
439458 |
1.13.11.34 | arachidonate 5-lipoxygenase |
mast cell |
mast cell line HMC-1 |
439465 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
mast cell |
isozyme NOS1 |
673804 |
1.14.16.4 | tryptophan 5-monooxygenase |
mast cell |
- |
728061 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
mast cell |
bone marrow-derived mast cell |
685384 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
mast cell |
- |
737400 |
2.7.1.138 | ceramide kinase |
mast cell |
- |
691364 |
2.7.1.138 | ceramide kinase |
mast cell |
bone marrow-derived mast cell |
693454 |
2.7.1.40 | pyruvate kinase |
mast cell |
- |
708734 |
2.7.1.91 | sphingosine kinase |
mast cell |
- |
704946 |
2.7.1.91 | sphingosine kinase |
mast cell |
secretion of sphinganine 1-phosphate |
661860 |
2.7.10.1 | receptor protein-tyrosine kinase |
mast cell |
- |
-, 490047, 490554, 672964, 673210, 674028, 693545 |
2.7.10.2 | non-specific protein-tyrosine kinase |
mast cell |
- |
490411, 675097 |
2.7.11.12 | cGMP-dependent protein kinase |
mast cell |
- |
675209 |
2.7.11.13 | protein kinase C |
mast cell |
derived from bone marrow |
662293 |
2.7.4.6 | nucleoside-diphosphate kinase |
mast cell |
of the mucosa, RBL-2H3 cell line |
642641, 642642 |
2.8.2.23 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 |
mast cell |
high expression level of HS3ST1 and low expression level of ZNF263 |
762294 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
mast cell |
high expression level of HS3ST1 and low expression level of ZNF263 |
762294 |
2.8.2.33 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase |
mast cell |
developed from bone marrow cells isolated from femur and tibia from C57BL/6 mice, mast cell maturation strongly correlates with the expression of GalNAc4S6ST |
-, 704949 |
2.8.2.5 | chondroitin 4-sulfotransferase |
mast cell |
developed from bone marrow cells isolated from femur and tibia from C57BL/6 mice, mast cell maturation strongly correlates with the expression of C4ST-1 |
-, 704949 |
2.8.2.8 | [heparan sulfate]-glucosamine N-sulfotransferase |
mast cell |
NDST-2 correlates strongly with mast cell maturation, whereas the expression of the NDST-1 isoform is approximately equal at all stages of maturation. NDST-1 expression is detected already in the early stage, day 0, bone marrow cells, but the level of expression does not increase throughout the process of mast cell maturation. NDST-2 expression follows an entirely different pattern, with low expression in day 0 and day 7 cultures, followed by a markedly increased level of expression starting from day 14 and has a continuously increased expression throughout the entire culture period. NDST-2 is downregulated after mast cell activation |
-, 704949 |
3.1.1.32 | phospholipase A1 |
mast cell |
peritoneal, isozyme PS-PLA1 or PLA1A |
678494 |
3.1.1.4 | phospholipase A2 |
mast cell |
- |
678633, 681856 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
mast cell |
- |
690673 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
mast cell |
outside the bone marrow |
691929 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
mast cell |
secretion of plasma isozyme |
653695 |
3.1.3.16 | protein-serine/threonine phosphatase |
mast cell |
umbilical cord derived mast cell |
692321 |
3.1.4.12 | sphingomyelin phosphodiesterase |
mast cell |
isolated from bone marrow or peritoneal lavage of gene-targeted mice lacking Asm and their wild-type littermates |
729609 |
3.1.4.4 | phospholipase D |
mast cell |
- |
707550, 751249 |
3.1.4.4 | phospholipase D |
mast cell |
peritoneal |
663560 |
3.1.4.4 | phospholipase D |
mast cell |
transformed bone marrow-derived mast cell line |
665917 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
mast cell |
PDE4 |
668987 |
3.3.2.6 | leukotriene-A4 hydrolase |
mast cell |
- |
708181 |
3.3.2.6 | leukotriene-A4 hydrolase |
mast cell |
bone marrow-derived |
-, 707085 |
3.4.11.3 | cystinyl aminopeptidase |
mast cell |
- |
670971 |
3.4.14.1 | dipeptidyl-peptidase I |
mast cell |
- |
36152 |
3.4.14.1 | dipeptidyl-peptidase I |
mast cell |
bone marrow mast cell |
665827 |
3.4.14.2 | dipeptidyl-peptidase II |
mast cell |
peritoneal, 10-20fold higher activity as compared with macrophages |
95234 |
3.4.17.1 | carboxypeptidase A |
mast cell |
- |
36323, 36325, 668215, 669629, 671003, 681146, 681199, 683036, 704153 |
3.4.17.1 | carboxypeptidase A |
mast cell |
from bone marrow, undifferentiated |
668068 |
3.4.17.1 | carboxypeptidase A |
mast cell |
granulated mast cell derived from undifferentiated mast cells by treatment 2 monoclonal antibodies, mAb-AA4 and mAb-BGD6 |
668068 |
3.4.17.1 | carboxypeptidase A |
mast cell |
mucosal mast cell |
683136 |
3.4.17.1 | carboxypeptidase A |
mast cell |
peritoneal |
667459 |
3.4.17.1 | carboxypeptidase A |
mast cell |
peritoneal, cathepsin B or E deficient |
669583 |
3.4.17.1 | carboxypeptidase A |
mast cell |
peritoneal, MCCPA localization analysis |
667459 |
3.4.17.1 | carboxypeptidase A |
mast cell |
the expression of human MC-CPA seems to be restricted to the MCTC subclass |
706874 |
3.4.17.15 | carboxypeptidase A2 |
mast cell |
peritoneal |
667459 |
3.4.21.107 | peptidase Do |
mast cell |
from cord blood, expression and enzyme content analysis, the enzyme is constitutively released from mast cells, overview |
683885 |
3.4.21.107 | peptidase Do |
mast cell |
peritoneal, mucosal, and connective tissue-derived mast cells, the enzyme expression is highly up-regulated during mucosal mast cell differentiation, enzyme levels in mucosal mast cells are much higher compared to connective-tissue-type mast cells, expression and enzyme content analysis, overview |
-, 683885 |
3.4.21.109 | matriptase |
mast cell |
- |
698077 |
3.4.21.109 | matriptase |
mast cell |
enzyme expression in normal and neoplastic mast cells, almost all different mast cells types in humans express matriptase, overview |
683423 |
3.4.21.20 | cathepsin G |
mast cell |
- |
653667, 664806 |
3.4.21.34 | plasma kallikrein |
mast cell |
active plasma kallikrein is localized to connective tissue-type mast cells in the mammary gland |
698893 |
3.4.21.37 | leukocyte elastase |
mast cell |
- |
647564 |
3.4.21.39 | chymase |
mast cell |
- |
29374, 29386, 678669, 679069, 679291, 679660, 680108, 680237, 680336, 681201, 681272, 681301, 681586, 681895, 681972, 682260, 682851, 697863, 698296, 699406, 700577, 701374, 709272, 717452, 717585, 717592, 717668, 717909, 731102, 731764, 731891, 731944, 732148, 732267, 732378, 732379, 732427, 732552, 732700, 732957, 752688, 752910, 753116, 753380, 753962, 81360, 81361, 81362, 81365, 81370, 81372, 81374, 81376, 81378, 81379, 81384, 81385 |
3.4.21.39 | chymase |
mast cell |
activated skin mast cell |
668072 |
3.4.21.39 | chymase |
mast cell |
chymase predominates in mast cells of connective tissue |
700007 |
3.4.21.39 | chymase |
mast cell |
peritoneal mast cell |
668245 |
3.4.21.39 | chymase |
mast cell |
recombinant enzyme |
668033 |
3.4.21.39 | chymase |
mast cell |
skin mast cell |
698223, 699923 |
3.4.21.39 | chymase |
mast cell |
skin-derived |
709741 |
3.4.21.4 | trypsin |
mast cell |
- |
697021 |
3.4.21.4 | trypsin |
mast cell |
tryptase is the most abundant mediator stored in mast cells |
700007 |
3.4.21.59 | Tryptase |
mast cell |
- |
29376, 29378, 29379, 29380, 29381, 29384, 29386, 29387, 29388, 29390, 29393, 29394, 29397, 29399, 29401, 29402, 29403, 29404, 29405, 29407, 29409, 670795, 680108, 683234, 683249, 683375, 683728, 683768, 695955, 697021, 697023, 697086, 697416, 698446, 699323, 699762, 699916, 700537, 708126, 708431, 708725, 708790, 709119, 709351, 710207, 717164, 717380, 717677, 717843, 717896, 718326, 731629, 732170, 752908, 752910, 753506, 753767, 754037, 754178 |
3.4.21.59 | Tryptase |
mast cell |
airway mast cells and mast cell-like cell line, HMC-1, delta-tryptase is primarily expressed by mast cells, in tissues such as colon, lung and heart as well as in HMC-1 cells |
683455 |
3.4.21.59 | Tryptase |
mast cell |
cell line HMC-1 obtained from a patient with mast cell leukemia |
29408 |
3.4.21.59 | Tryptase |
mast cell |
from liver capsule |
29378, 29392 |
3.4.21.59 | Tryptase |
mast cell |
mast cell protease-11 is highly expressed by primary basophils and to a much lesser extent, by some mast cells |
709414 |
3.4.21.59 | Tryptase |
mast cell |
mast cell tryptase activates peripheral blood eosinophils to release granule-associated enzymes |
668951 |
3.4.21.59 | Tryptase |
mast cell |
mMCP-6 is exclusively expressed in connective tissuetype mast cells, mMCP-7 occurs in early stage cultures of bone marrow-derived mast cells, MCP-11 expression is highest at early stages of mast cell development |
683455 |
3.4.21.59 | Tryptase |
mast cell |
peritoneal |
29374, 29378, 29389 |
3.4.21.59 | Tryptase |
mast cell |
present in pituitary connective tissue |
29377 |
3.4.21.59 | Tryptase |
mast cell |
propagated in nude mice |
29391 |
3.4.21.59 | Tryptase |
mast cell |
pulmonary mast cell |
701383 |
3.4.21.59 | Tryptase |
mast cell |
skin mast cell |
697086 |
3.4.21.59 | Tryptase |
mast cell |
synthesis |
683545 |
3.4.21.59 | Tryptase |
mast cell |
tryptase predominates in mast cells of mucosal tissue |
700007 |
3.4.21.68 | t-Plasminogen activator |
mast cell |
from lung |
717938 |
3.4.21.79 | granzyme B |
mast cell |
- |
709759, 755124 |
3.4.21.79 | granzyme B |
mast cell |
cord blood- and mature skin-derived mast cells. Majority of lesional mast cells express abundant GrB |
681967 |
3.4.21.79 | granzyme B |
mast cell |
skin-, but not lung-associated primary mast cells as well as in vitro-differentiated bone marrow-derived mast cells express GzmB |
679099 |
3.4.21.B3 | duodenase |
mast cell |
spindle or stellate-shaped, located pricipally in the lamina propria and submucosa |
658604 |
3.4.21.B5 | mast cell protease 5 |
mast cell |
- |
650277, 697030, 754154 |
3.4.21.B5 | mast cell protease 5 |
mast cell |
of the connective tissue mast cell stage |
651180 |
3.4.21.B5 | mast cell protease 5 |
mast cell |
serosal mast cell and Kirsten sarcoma virus-immortalized mast cell |
653603 |
3.4.21.B5 | mast cell protease 5 |
mast cell |
serosal mast cells, Kirsten sarcoma virus-immortalized mast cells, and bone marrow-derived mast cells, but not in gastrointestinal mucosal mast cells of helmith-infected mice |
651841 |
3.4.22.15 | cathepsin L |
mast cell |
cathepsin is expressed in mast cells, but is not required for the activation of dipeptidyl peptidase I |
667867 |
3.4.22.36 | caspase-1 |
mast cell |
- |
707321 |
3.4.22.62 | caspase-9 |
mast cell |
- |
664448 |
3.4.23.34 | cathepsin E |
mast cell |
- |
669583 |
3.4.24.35 | gelatinase B |
mast cell |
secretion of MMP-9 |
-, 683525 |
3.4.24.35 | gelatinase B |
mast cell |
treatment of blood-derived mast cells with TNF-alpha significantly increases expression of enzyme mRNA and upregulates enzyme activity. TNF-alpha also increases the invasiveness of mast cells across Matrigel-coated membranes. INF-gamma is inhibitory to enzyme mRNA and protein expression |
669731 |
3.6.1.2 | trimetaphosphatase |
mast cell |
- |
209930, 209939 |
3.6.1.2 | trimetaphosphatase |
mast cell |
peritoneal granules not reactive for TMPase |
209941 |
3.6.4.6 | vesicle-fusing ATPase |
mast cell |
modest expression |
755920 |
4.1.1.22 | histidine decarboxylase |
mast cell |
- |
714942 |