EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
macrophage |
activity occurs after differentiation of neutrophils to macrophages |
669730 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
macrophage |
derived from bone-marrow, peritoneal macrophages, expression of isozyme 11beta-HSD1, not isozyme 11beta-HSD2 |
669730 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
macrophage |
isoform 11betaHSD2 |
741066 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
macrophage |
- |
286017 |
1.1.1.188 | prostaglandin-F synthase |
macrophage |
peritoneal |
654851 |
1.1.1.21 | aldose reductase |
macrophage |
- |
-, 669503, 738833, 739113 |
1.1.1.21 | aldose reductase |
macrophage |
in inflamed temporal arteries |
668868 |
1.1.1.271 | GDP-L-fucose synthase |
macrophage |
- |
667231 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
macrophage |
- |
655495 |
1.11.2.2 | myeloperoxidase |
macrophage |
- |
697307, 700458 |
1.13.11.11 | tryptophan 2,3-dioxygenase |
macrophage |
- |
743358 |
1.13.11.31 | arachidonate 12-lipoxygenase |
macrophage |
- |
-, 704947, 726846, 741573 |
1.13.11.31 | arachidonate 12-lipoxygenase |
macrophage |
12/15-LOX is a macrophage-selective regulator of interleukin-12 production |
-, 704003 |
1.13.11.31 | arachidonate 12-lipoxygenase |
macrophage |
12/15-LOX is expressed by 95% of resident peritoneal CD11bhigh cells, with the remaining 5% being 12/15-LOX-. 12/15-LOX+ cells are phenotypically defined by high F4/80, SR-A, and Siglec1 expression, and enhanced IL-10 and G-CSF generation. In contrast, 12/15-LOX- cells are a dendritic cell population. Resident peritoneal macrophage numbers are significantly increased in 12/15-LOX-/- mice, suggesting alterations in migratory trafficking or cell differentiation in vivo |
-, 704943 |
1.13.11.31 | arachidonate 12-lipoxygenase |
macrophage |
macrophages that overexpress 12/15LO have reduced ATP-binding cassette G1 expression, increased transporter phosphorylation, and reduced cholesterol efflux |
704567 |
1.13.11.31 | arachidonate 12-lipoxygenase |
macrophage |
peritoneal |
-, 684803 |
1.13.11.31 | arachidonate 12-lipoxygenase |
macrophage |
resident peritoneal |
742000 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
- |
703628, 742239 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
12/15-LOX is a macrophage-selective regulator of interleukin-12 production |
-, 704003 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
12/15-LOX is expressed by 95% of resident peritoneal CD11bhigh cells, with the remaining 5% being 12/15-LOX-. 12/15-LOX+ cells are phenotypically defined by high F4/80, SR-A, and Siglec1 expression, and enhanced IL-10 and G-CSF generation. In contrast, 12/15-LOX- cells are a dendritic cell population. Resident peritoneal macrophage numbers are significantly increased in 12/15-LOX-/- mice, suggesting alterations in migratory trafficking or cell differentiation in vivo |
-, 704943 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
alveolar |
742613 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
high level expression in peritoneal macrophages, while murine peripheral monocytes, alveolar macrophages and bone marrow-derived macrophages express alox15 only at low levels |
742613 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
isozyme 15-LO-1, differentiated monocytes obtained from human venous blood, CD14+ |
687235 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
peritoneal |
-, 684350 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
resident peritoneal |
742000 |
1.13.11.33 | arachidonate 15-lipoxygenase |
macrophage |
rheumatoid arthritis tissue |
701978 |
1.13.11.34 | arachidonate 5-lipoxygenase |
macrophage |
- |
660111, 704997, 711100, 713540, 743614 |
1.13.11.34 | arachidonate 5-lipoxygenase |
macrophage |
alveolar macrophage |
742001 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
macrophage |
- |
666461, 711952, 743358 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
macrophage |
enzyme is induced in monocyte-derived macrophages treated with human recombinant interferon-beta or interferon gamma |
395468 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
macrophage |
in the villous stroma and in the fetal membrane |
659803 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
macrophage |
- |
745510 |
1.14.11.68 | [histone H3]-trimethyl-L-lysine27 demethylase |
macrophage |
expressed in macrophages in response to bacterial products and inflammatory cytokines |
753165 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
- |
-, 440193, 440195, 440198, 440204, 440206, 440207, 440208, 440209, 440219, 440226, 440234, 440236, 674558 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
alveolar |
690183 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
bone marrow-derived |
687727 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
Ca2+-independent form |
440200, 440201 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
cytokine-activated |
440192, 440200, 440219 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
in liver, lung, kidney, isoform II |
440226 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
inducible enzyme |
671728 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
iNOS |
687358 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
iNOS is the predominant isozyme in macrophages |
695853 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
NOS2 |
701646 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
macrophage |
RAW 264.7 cells |
440219, 440221, 440222, 440223, 440225, 440236, 440238 |
1.14.13.9 | kynurenine 3-monooxygenase |
macrophage |
- |
763915, 764034 |
1.14.13.9 | kynurenine 3-monooxygenase |
macrophage |
in first and second trimester of the placenta, within the fetal villus |
660112 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
macrophage |
- |
684920, 685498, 686078, 688061, 688881, 705614, 733904 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
macrophage |
peritoneal, alveolar |
438244 |
1.14.14.29 | 25/26-hydroxycholesterol 7alpha-hydroxylase |
macrophage |
bone marrow-derived |
699414 |
1.14.15.15 | cholestanetriol 26-monooxygenase |
macrophage |
- |
703582 |
1.14.15.18 | calcidiol 1-monooxygenase |
macrophage |
- |
675057, 675686 |
1.14.15.18 | calcidiol 1-monooxygenase |
macrophage |
expression of 1alpha-hydroxylase is intimately associated with toll-like receptor, TLR, recognition of pathogens in macrophages |
712885 |
1.14.15.18 | calcidiol 1-monooxygenase |
macrophage |
monocyte-derived |
688675 |
1.14.16.5 | alkylglycerol monooxygenase |
macrophage |
- |
746303 |
1.14.99.38 | cholesterol 25-monooxygenase |
macrophage |
- |
-, 699414, 700999, 715833, 744738 |
1.14.99.38 | cholesterol 25-monooxygenase |
macrophage |
testicular |
658244, 658246 |
1.14.99.38 | cholesterol 25-monooxygenase |
macrophage |
testicular, 10-day-old animals have the highest steady-state levels of message |
658245 |
1.15.1.1 | superoxide dismutase |
macrophage |
- |
685864 |
1.15.1.1 | superoxide dismutase |
macrophage |
peritoneal macrophages exposed to He-Ne laser radiation. Changes in the activity of superoxide dismutase as well as the formation of nitric oxide and peroxynitrite depend to a large extent on the laser radiation dose. Activation of enzyme at low radiation doses is accompanied by nitric oxide level increase without changes in peroxynitrite. Enhanced laser radiation doses inhibit the enzyme |
672292 |
1.16.3.1 | ferroxidase |
macrophage |
- |
438021 |
1.17.3.2 | xanthine oxidase |
macrophage |
alveolar macrophages purified from the lung by lavage, and interstitial macrophages. Inflammatory cells express high levels of XOR activity, while in resident alveolar macrophage the enzyme content is extremely low prior to cytokine insufflation |
-, 715663 |
1.2.1.104 | pyruvate dehydrogenase system |
macrophage |
- |
763502 |
1.2.1.13 | glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) |
macrophage |
peritoneal |
288005 |
1.2.1.36 | retinal dehydrogenase |
macrophage |
hepatic |
743375 |
1.2.4.1 | pyruvate dehydrogenase (acetyl-transferring) |
macrophage |
- |
763502 |
1.3.1.21 | 7-dehydrocholesterol reductase |
macrophage |
- |
763129 |
1.3.1.24 | biliverdin reductase |
macrophage |
- |
673797, 698922, 740486, 740549 |
1.3.1.24 | biliverdin reductase |
macrophage |
increased expression in macrophages of primary spontaneous pneumothorax of smokers compared to non-smokers |
713359 |
1.3.1.24 | biliverdin reductase |
macrophage |
lung |
713359 |
1.4.3.2 | L-amino-acid oxidase |
macrophage |
- |
726320 |
1.4.3.2 | L-amino-acid oxidase |
macrophage |
immunostaining in macrophages associated with non small-cell lung carcinomas, mesotheliomas, colorectal carcinomas and testicular germ cell tumors, positive staining in germinal centers of reactive lymph nodes and hyperplastic tonsils, and in the spleen |
699933 |
1.5.3.16 | spermine oxidase |
macrophage |
- |
725128, 741582 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
macrophage |
bone marrow-derived, Nnt mRNA and protein are expressed in resting macrophages and down-regulated in response to inflammatory stimuli such as lipopolysaccharide. Nnt mRNA and protein expression are further repressed in fully activated macrophages |
724953 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
macrophage |
bone marrow-derived, Nnt mRNA and protein are expressed in resting macrophages and down-regulated in response to inflammatory stimuli such as lipopolysaccharide. Nnt mRNA and protein expression are repressed in fully activated macrophages |
724953 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
macrophage |
- |
742310, 743287 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
macrophage |
alveolar macrophages. Inhibition of NAD(P)H oxidase by apocynin results in down-regulation of arginase |
686562 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
macrophage |
Burkholderia cenocepacia resides in macrophage vacuoles displaying an altered recruitment of the NADPH oxidase complex at the phagosomal membrane |
700052 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
macrophage |
isoforms NOX2 and NOX4 |
742567 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
macrophage |
enzyme is highly upregulated in active and chronic multiple sclerosis lesions, particularly in hypertrophic astrocytes and myelin-laden macrophages |
673798 |
1.8.1.7 | glutathione-disulfide reductase |
macrophage |
- |
690144 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
macrophage |
highly expressed in immune-activated macrophages |
765804 |
1.8.4.2 | protein-disulfide reductase (glutathione) |
macrophage |
- |
394863 |
2.1.1.319 | type I protein arginine methyltransferase |
macrophage |
- |
756732 |
2.1.1.355 | [histone H3]-lysine9 N-trimethyltransferase |
macrophage |
- |
755432 |
2.1.1.360 | [histone H3]-lysine79 N-trimethyltransferase |
macrophage |
- |
753191 |
2.1.1.364 | [histone H3]-lysine4 N-methyltransferase |
macrophage |
- |
704436 |
2.1.1.366 | [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase |
macrophage |
- |
755432 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
macrophage |
- |
701644 |
2.2.1.1 | transketolase |
macrophage |
at the lesion border |
694176 |
2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) |
macrophage |
- |
16268 |
2.3.1.148 | glycerophospholipid acyltransferase (CoA-dependent) |
macrophage |
- |
16278 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
macrophage |
bone marrow-derived macrophages |
-, 756014 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
macrophage |
- |
704461, 736546, 756102 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
macrophage |
primary peripheral blood macrophages |
735571 |
2.3.1.26 | sterol O-acyltransferase |
macrophage |
- |
486696, 486703, 684800, 702552, 702650, 703975, 736792 |
2.3.1.26 | sterol O-acyltransferase |
macrophage |
ACAT1, villus |
486708 |
2.3.1.26 | sterol O-acyltransferase |
macrophage |
loss of ACAT activity in macrophages, either by pharmacological inhibition or by genetic knockout of ACAT-1, results in reduced induction of apoptosis in response to 7-ketocholesterol or oxidized low density lipoproteins. The apoptotic signal generated in macrophages by ACAT may be an arachidonyl oxysterol |
675261 |
2.3.1.26 | sterol O-acyltransferase |
macrophage |
monocyte-derived macrophage |
684780 |
2.3.1.26 | sterol O-acyltransferase |
macrophage |
relative high level of mRNA |
486703 |
2.3.1.48 | histone acetyltransferase |
macrophage |
- |
-, 702855 |