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Search term: hepatoma cell line

Results 1 - 25 of 25
EC Number
Source Tissue
Commentary
Reference
peptide-aspartate beta-dioxygenase
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peptide-aspartate beta-dioxygenase
increased expression of aspartate beta-hydroxylase in hepatocellular carcinoma tissues is associated with tumor invasiveness and a worse prognosis. Aspartate beta-hydroxylase overexpression in hepatocellular carcinoma tissues is correlated with decreased copy numbers of displacement loop (D-loop) and NADH dehydrogenase subunit 1 and enhanced D-loop mutation, suggesting the disrupted mitochondrial DNA (mtDNA) stability. The reduced mtDNA copy numbers are associated with aggressive clinicopathological features of hepatocellular carcinoma. The loss of mtDNA integrity induced by enforced expression of Aspartate beta-hydroxylase is accompanied with mitochondrial dysfunction, which is characterized by the aberrant mitochondrial membrane potential, decreased ATP generation and enhanced reactive oxygen species. The enzyme interacts with histone H2A member X. Overexpression of aspartate beta-hydroxylase diminishes the interaction between histone H2A member X and mitochondrial transcription factor A (mtTFA), an important DNA-binding protein for mtDNA replication, which then reduced the binding of mtTFA to D-loop region. Overexpression of aspartate beta-hydroxylase disrupts the mtDNA integrity through H2AX-mtTFA signal, thereby affecting mitochondrial functions in hepatocellular carcinoma
phytanoyl-CoA dioxygenase
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alkane 1-monooxygenase
-
D-amino-acid oxidase
101L cell
pyrroline-5-carboxylate reductase
full-length sequence is amplified from a hepatoma cell line cDNA library
betaine-homocysteine S-methyltransferase
hyperosmolarity (405 mosmol/l) suppresses Bhmt mRNA expression whereas hypoosmotic (205 mosmol/l) conditions induce Bhmt mRNA expression. Like hyperosmotic NaCl, hyperosmotic raffinose but not hyperosmotic urea suppresses Bhmt mRNA expression. Osmosensitivity of Bhmt mRNA expression is impaired by inhibitors of tyrosine kinases and cyclic nucleotide-dependent kinases
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
7721 cell
alkylglycerone-phosphate synthase
the enzyme is upregulated in multiple types of cancer cells and primary tumors
hexokinase
AS-30D, highly glycolytic tumor cells
glycerol kinase
HaIIE (ATCC)
choline kinase
Hepa-1
mevalonate kinase
cell line PLC/PRF/5
non-specific protein-tyrosine kinase
PLC cell
nucleoside-diphosphate kinase
Novikoff
3-oxoacid CoA-transferase
H1e human hepatoma cell line, but no detection in normal hepatocytes, HepG2 hepatoma cells and liver tissues
phosphodiesterase I
PLC/ PRF/5 human hepatoma
mannosyl-oligosaccharide alpha-1,3-glucosidase
-
t-Plasminogen activator
transformed
histidine decarboxylase
-
phosphoenolpyruvate carboxykinase (GTP)
H4IIEC3 cells, mRNA is 5-10fold elevated in cells cultured at high density compared to low density, KRC-7 cells, an H4IIEC3 subclone, are much more sensitive to growth arrest than its parental cell line
phosphoenolpyruvate carboxykinase (GTP)
Reuber H365 hepatoma cells
carbonic anhydrase
-
GMP synthase (glutamine-hydrolysing)
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Results 1 - 25 of 25