EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.300 | NADP-retinol dehydrogenase |
glioma cell |
high RDH10 expression level, 13.89%, 43.59%, 70.59%, and 90.24% expression of RDH10 in glioma of grade I, II, III, and IV (WHO grading), respectively |
762073 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
glioma cell |
- |
761332 |
1.1.1.41 | isocitrate dehydrogenase (NAD+) |
glioma cell |
- |
712180 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
- |
712180, 712574, 712614, 713113, 739984 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
IDH1, diffuse gliomas graded II-IV |
713508 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
of grade II-III gliomas |
713100 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
progressive gliomas |
711107 |
1.13.11.31 | arachidonate 12-lipoxygenase |
glioma cell |
- |
688759 |
1.13.11.34 | arachidonate 5-lipoxygenase |
glioma cell |
- |
688512 |
1.13.11.34 | arachidonate 5-lipoxygenase |
glioma cell |
high enzyme expression level |
686278 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
glioma cell |
- |
756531 |
1.14.14.14 | aromatase |
glioma cell |
- |
726047 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
glioma cell |
- |
690140 |
1.14.15.18 | calcidiol 1-monooxygenase |
glioma cell |
- |
659811 |
1.14.16.4 | tryptophan 5-monooxygenase |
glioma cell |
- |
687604 |
1.14.19.17 | sphingolipid 4-desaturase |
glioma cell |
- |
744686 |
1.2.1.24 | succinate-semialdehyde dehydrogenase (NAD+) |
glioma cell |
astrocytomas and oligodendrogliomas |
763330 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
glioma cell |
- |
741427 |
1.4.1.3 | glutamate dehydrogenase [NAD(P)+] |
glioma cell |
gene expression profiling reveals that GLUD2 is selectively and consistently upregulated in glioma cells harboring IDH mutations |
762783 |
1.4.3.4 | monoamine oxidase |
glioma cell |
activity selectively increases in MAO-B activity in human gliomas when compared with meningiomas or non-tumoural tissue |
689175 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
glioma cell |
- |
673219, 701644, 705897 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
glioma cell |
biopsies |
688740 |
2.1.2.1 | glycine hydroxymethyltransferase |
glioma cell |
expression of SHMT2 in ischemic tumor zones |
736882 |
2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 |
glioma cell |
the enzyme is frequently overexpressed in glioma, enzyme immunohistochemic analysis in 70 cases of human gliomas and normal brain tissues, overview |
736945 |
2.3.1.299 | sphingoid base N-stearoyltransferase |
glioma cell |
- |
757888 |
2.3.1.48 | histone acetyltransferase |
glioma cell |
- |
756850 |
2.3.1.57 | diamine N-acetyltransferase |
glioma cell |
- |
757876 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
glioma cell |
SIRT6 is down-regulated in human glioma tissues |
729145 |
2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
glioma cell |
cell proliferation and migration analysis, overview |
759196 |
2.4.1.109 | dolichyl-phosphate-mannose-protein mannosyltransferase |
glioma cell |
of brain with subarachnoid spread. Distinct POMT1 alterations may contribute to a functional impairment of protein-omannosyltransferase activity. In individual tumor specimens selective alterations of the POMT1 gene may be compatible with clonal evolution of distinct sublocations |
689201 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
glioma cell |
- |
736507 |
2.4.1.175 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase |
glioma cell |
CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival |
759875 |
2.4.1.212 | hyaluronan synthase |
glioma cell |
cell line |
395258 |
2.4.1.224 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
glioma cell |
- |
759360 |
2.4.1.225 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase |
glioma cell |
- |
759360 |
2.4.1.226 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase |
glioma cell |
CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival |
759875 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
glioma cell |
- |
685932, 718736 |
2.4.1.47 | N-acylsphingosine galactosyltransferase |
glioma cell |
human fetal glioma cell line |
489221 |
2.4.1.47 | N-acylsphingosine galactosyltransferase |
glioma cell |
N-370 FG cells |
489221, 489224 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
glioma cell |
- |
735872 |
2.4.2.3 | uridine phosphorylase |
glioma cell |
UPP1 is significantly upregulated in glioma, especially in glioblastoma |
758991 |
2.5.1.26 | alkylglycerone-phosphate synthase |
glioma cell |
- |
737578, 739210 |
2.6.1.42 | branched-chain-amino-acid transaminase |
glioma cell |
- |
758657 |
2.7.1.1 | hexokinase |
glioma cell |
hexokinase I, predominant in normal brain |
640259 |
2.7.1.1 | hexokinase |
glioma cell |
hexokinase II, increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line |
640259 |
2.7.1.105 | 6-phosphofructo-2-kinase |
glioma cell |
- |
739621, 761915 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
glioma cell |
human glioma cell line HTB-138, InsP3 3-kinase B mRNA |
640751 |
2.7.1.137 | phosphatidylinositol 3-kinase |
glioma cell |
- |
709276 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
glioma cell |
- |
709907 |
2.7.1.3 | ketohexokinase |
glioma cell |
expressed at significantly higher level in glioma tissues than in non-tumor brain |
758732 |
2.7.1.94 | acylglycerol kinase |
glioma cell |
- |
761230 |
2.7.10.2 | non-specific protein-tyrosine kinase |
glioma cell |
- |
721489 |
2.7.11.11 | cAMP-dependent protein kinase |
glioma cell |
- |
662380 |
2.7.11.13 | protein kinase C |
glioma cell |
- |
676323 |
2.7.11.20 | elongation factor 2 kinase |
glioma cell |
- |
760810 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
glioma cell |
- |
760351 |
2.7.12.2 | mitogen-activated protein kinase kinase |
glioma cell |
MKK3 i s upregulated and activated in invasive glioma cells in vitro, overexpression and phosphorylation of MKK3 are linked to glioma invasion, MKK3 is overexpressed in invasive glioma cells in situ and correlates with active p38 |
681871 |
2.7.8.11 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase |
glioma cell |
- |
645316 |
2.7.8.27 | sphingomyelin synthase |
glioma cell |
- |
737747 |
2.8.2.17 | chondroitin 6-sulfotransferase |
glioma cell |
- |
761061 |
2.8.2.23 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 |
glioma cell |
- |
759360 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
glioma cell |
- |
759360 |
2.8.2.8 | [heparan sulfate]-glucosamine N-sulfotransferase |
glioma cell |
- |
759360 |
3.1.1.89 | protein phosphatase methylesterase-1 |
glioma cell |
in human glioma cell, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance |
749865 |
3.1.3.16 | protein-serine/threonine phosphatase |
glioma cell |
- |
692085, 750280 |
3.1.3.5 | 5'-nucleotidase |
glioma cell |
- |
694138 |
3.1.3.7 | 3'(2'),5'-bisphosphate nucleotidase |
glioma cell |
in glioma tissues, phosphocholine(36:1) is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated, quantitative real-time polymerase chain reaction (qRT-PCR) expression analysis. Gene expression of enzymes associated with pAp metabolism |
752237 |
3.1.3.77 | acireductone synthase |
glioma cell |
- |
751767 |
3.1.4.11 | phosphoinositide phospholipase C |
glioma cell |
C6Bu-1 rat glioma cell, isoenzyme PI-PLC-beta1 |
668867 |
3.1.4.12 | sphingomyelin phosphodiesterase |
glioma cell |
C6-glioma cells |
652974 |
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
glioma cell |
- |
135401 |
3.1.4.4 | phospholipase D |
glioma cell |
- |
708012 |
3.1.6.13 | iduronate-2-sulfatase |
glioma cell |
- |
650371 |
3.2.1.143 | poly(ADP-ribose) glycohydrolase |
glioma cell |
primary culture, highest ratio of nuclear to cytoplasmic enzyme activity |
664476 |
3.2.1.166 | heparanase |
glioma cell |
- |
693320, 759360 |
3.2.1.45 | glucosylceramidase |
glioma cell |
- |
751699 |
3.3.2.6 | leukotriene-A4 hydrolase |
glioma cell |
- |
752495 |
3.4.14.5 | dipeptidyl-peptidase IV |
glioma cell |
- |
703784 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
glioma cell |
- |
710451 |
3.4.21.109 | matriptase |
glioma cell |
- |
717799 |
3.4.21.26 | prolyl oligopeptidase |
glioma cell |
- |
669933, 683344 |
3.4.21.73 | u-Plasminogen activator |
glioma cell |
- |
710121 |
3.4.21.75 | Furin |
glioma cell |
- |
708753 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
glioma cell |
- |
707629 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
glioma cell |
increased enzyme expression in a subgroup of high-grade gliomas. The enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth |
755628 |
3.4.22.1 | cathepsin B |
glioma cell |
astrocytic |
707558 |
3.4.22.15 | cathepsin L |
glioma cell |
- |
712921 |
3.4.22.60 | caspase-7 |
glioma cell |
- |
700938 |
3.4.22.61 | caspase-8 |
glioma cell |
- |
664508 |
3.4.22.61 | caspase-8 |
glioma cell |
stem-cell-like and non-stem-cell-like glioma cell |
695401 |
3.4.22.61 | caspase-8 |
glioma cell |
stem-cell-like glioma cell, low enzyme expression levels due to hypermethylation of the CASP8 promoter, also expressed in non-stem-like glioma cell |
695401 |
3.4.22.62 | caspase-9 |
glioma cell |
- |
665736 |
3.4.22.B70 | SENP1 peptidase |
glioma cell |
- |
753729 |
3.4.24.17 | stromelysin 1 |
glioma cell |
- |
708089 |
3.4.24.23 | matrilysin |
glioma cell |
highly variable MMP-7 expression in the glioma population |
683864 |
3.4.24.24 | gelatinase A |
glioma cell |
high expression level of MMP-2 increasing during growth |
683427 |
3.4.24.35 | gelatinase B |
glioma cell |
high expression level of MMP-9 increasing during growth |
683427 |
3.4.24.82 | ADAMTS-4 endopeptidase |
glioma cell |
- |
638956 |
3.4.24.B4 | matrix metalloproteinase-13 |
glioma cell |
- |
711163 |
3.4.24.B7 | matrix metalloproteinase-26 |
glioma cell |
- |
713160, 754946 |