EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.4.22.1 | cathepsin B |
breast cancer cell |
- |
36625, 753138 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
breast cancer cell |
- |
287331 |
1.14.11.16 | peptide-aspartate beta-dioxygenase |
breast cancer cell |
highly expressed |
439254 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
breast cancer |
490443 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
breast carcinomas |
490594 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
breast tumours |
490596 |
3.4.22.59 | caspase-6 |
breast cancer cell |
- |
647467 |
3.1.6.2 | steryl-sulfatase |
breast cancer cell |
expression of STS mRNA and STS activity are increased in malignant breast tissues compared with that in non-malignant tissues |
656640 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
- |
656788, 763397 |
2.5.1.60 | protein geranylgeranyltransferase type II |
breast cancer cell |
- |
658377 |
2.1.1.6 | catechol O-methyltransferase |
breast cancer cell |
- |
658443, 702678 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
breast cancer cell |
- |
659398 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
- |
490442, 490457, 490469, 661457, 662172, 662174, 676266, 691526 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
overexpression of Her2-receptor |
661551 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
breast cancer cell |
isozyme 3beta-HSD1 |
662371 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
overexpression of EGFR-TK |
662724 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
breast cancer cell |
- |
662996, 761128 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
breast cancer cell |
differential expression of CaM-KI and CaM-KII in cell lines MCF-7 and MCF-10A |
664506 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast cancer cell |
enzyme expression analysis in 155 patients, overview |
664622 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
breast cancer cell |
- |
664865 |
2.7.11.22 | cyclin-dependent kinase |
breast cancer cell |
- |
491470, 665497, 681873, 723656 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
breast cancer cell |
high expression level of MEKK3 |
665600 |
2.7.11.24 | mitogen-activated protein kinase |
breast cancer cell |
- |
665638 |
3.4.21.B41 | kallikrein 10 |
breast cancer cell |
downregulation due to hypermethylation of exon 3 |
667874 |
3.6.5.2 | small monomeric GTPase |
breast cancer cell |
mRNA levels of RasL10B are down-regulated in all breast cancer cells tested (HBL100, MCF7, MDA-MB-468, MDA-MB-231 and MDA-MB-435. RasL10B) is a member of ras superfamily with tumor suppressor potential |
668060 |
3.4.22.41 | cathepsin F |
breast cancer cell |
- |
668085 |
3.4.21.B45 | kallikrein 14 |
breast cancer cell |
KLK14 expression significantly higher compared to normal breast tissues |
668103 |
3.4.22.26 | cancer procoagulant |
breast cancer cell |
- |
668137 |
3.4.24.B3 | matrix metalloproteinase-11 |
breast cancer cell |
cancer cell-adipocyte interaction/crosstalk during the initial steps of cancer cell invasion |
668150 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
breast cancer cell |
expression of the enzyme and the estrogen receptor is correlated |
668162 |
3.5.4.4 | adenosine deaminase |
breast cancer cell |
the activity of isozyme ADA2 is increased |
668272 |
3.4.23.3 | gastricsin |
breast cancer cell |
- |
668809 |
3.5.1.2 | glutaminase |
breast cancer cell |
- |
670391, 694485 |
3.4.24.B10 | ADAM12 endopeptidase |
breast cancer cell |
- |
670445, 719935, 754703, 754704, 755485 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast cancer cell |
no expression |
670978 |
2.7.1.91 | sphingosine kinase |
breast cancer cell |
- |
671356 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast cancer cell |
- |
671357, 695621 |
2.7.1.32 | choline kinase |
breast cancer cell |
- |
671362, 672898, 723311, 759595, 760183 |
1.14.15.18 | calcidiol 1-monooxygenase |
breast cancer cell |
the enzyme expression is reduced in breast cancer cell specimen compared to healthy breast tissue |
672857 |
6.3.2.2 | glutamate-cysteine ligase |
breast cancer cell |
treatment of human breast cancer cells with 2-deoxy-D-glucose causes metabolic oxidative stress that is accompanied by increases in steady-state levels of glutamate cysteine ligase mRNA, glutamate cysteine ligase activity and glutathione content |
672904 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
breast cancer cell |
- |
672907 |
6.4.1.2 | acetyl-CoA carboxylase |
breast cancer cell |
- |
672908, 675919 |
2.7.10.2 | non-specific protein-tyrosine kinase |
breast cancer cell |
PYK2 |
673223 |
1.14.13.8 | flavin-containing monooxygenase |
breast cancer cell |
- |
673313 |
2.4.2.3 | uridine phosphorylase |
breast cancer cell |
negative correlation between UPase expression and the clinical outcome of breast cancer |
673810 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
breast cancer cell |
neoplastic and adjacent, non-neoplastic glandular breast tissue specimens from human patients, expression analysis, reduced enzyme expression, LRAT protein progressively decreases with a reduction in the degree of tumor differentiation in invasive breast carcinomas, overview |
674069 |
2.8.2.4 | estrone sulfotransferase |
breast cancer cell |
invasive, postmenopausal women |
674994 |
2.8.2.4 | estrone sulfotransferase |
breast cancer cell |
preinvasive and invasive cancer cells |
674994 |
1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) |
breast cancer cell |
- |
675678 |
1.2.1.31 | L-aminoadipate-semialdehyde dehydrogenase |
breast cancer cell |
- |
675897 |
1.8.1.9 | thioredoxin-disulfide reductase |
breast cancer cell |
- |
675915 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
patients with ductal carcinoma |
676155 |
2.7.11.10 | IkappaB kinase |
breast cancer cell |
- |
676886 |
1.13.11.33 | arachidonate 15-lipoxygenase |
breast cancer cell |
- |
676925 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
breast cancer cell |
- |
677235 |
3.4.14.9 | tripeptidyl-peptidase I |
breast cancer cell |
- |
678513 |
3.4.21.35 | tissue kallikrein |
breast cancer cell |
- |
678522, 752895 |
3.4.21.B41 | kallikrein 10 |
breast cancer cell |
- |
678524, 678530, 679256 |
3.4.21.B25 | PACE4 proprotein convertase |
breast cancer cell |
- |
679039 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
breast cancer cell |
UCH-L3 mRNA level is significantly upregulated and UHCL1 mRNA level also show a non-significant increase in breast cancer tissue compared to adjacent normal breast tissue. Both UCH-L1 and UCH-L3 mRNA levels are significantly higher in high histological grade tumors than in low histological grade tumors. UCH-L1 mRNA level in tumors is approximately 10 times higher than that of UCH-L3 |
679040 |
3.1.3.2 | acid phosphatase |
breast cancer cell |
- |
679089 |
3.4.21.B43 | kallikrein 12 |
breast cancer cell |
- |
679276 |
3.4.22.59 | caspase-6 |
breast cancer cell |
invasive operable pT1 and pT2 ductal breast carcinoma are analysed of 210 patients: caspase-6 is overexpressed in 52.9% |
680072 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
breast cancer cell |
- |
681814, 727322 |
2.7.12.2 | mitogen-activated protein kinase kinase |
breast cancer cell |
impaired expression of MKK4 |
682214 |
3.1.3.5 | 5'-nucleotidase |
breast cancer cell |
- |
682217, 691078, 693298, 750845 |
3.1.6.2 | steryl-sulfatase |
breast cancer cell |
- |
682219, 706776 |
2.7.2.3 | phosphoglycerate kinase |
breast cancer cell |
moderate PGK1 expression |
682792 |
4.1.1.17 | ornithine decarboxylase |
breast cancer cell |
- |
682982, 695299 |
3.4.24.23 | matrilysin |
breast cancer cell |
early stage primary cancers, MMP-7 correlates with breast cancer development, overexpression of MMP-7 and ErbB4, overview |
683331 |
3.4.21.109 | matriptase |
breast cancer cell |
- |
683364, 683489, 683492, 683494, 683763, 683893, 695463, 717902 |
3.4.19.9 | folate gamma-glutamyl hydrolase |
breast cancer cell |
- |
683368 |
3.4.13.9 | Xaa-Pro dipeptidase |
breast cancer cell |
breast cancer tissue shows high enzyme activity, reduced collagen content and decreased expression of beta1-integrins |
683557 |
3.4.24.56 | insulysin |
breast cancer cell |
- |
683571 |
2.4.2.4 | thymidine phosphorylase |
breast cancer cell |
- |
684460, 684466, 686140, 688302, 705495 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
- |
685545, 711649, 713021, 726302, 740542, 740839, 740849, 761756, 761900 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
breast cancer cell |
MDA-MB-231 (doxorubicin resistant) human breast cancer cell |
685934 |
1.4.3.13 | protein-lysine 6-oxidase |
breast cancer cell |
lymph node-negative breast adenocarcinoma cell |
685957 |
2.7.1.137 | phosphatidylinositol 3-kinase |
breast cancer cell |
ER-positive breast cancer cells (UMB-1Ca) are grown as tumors in ovariectomized athymic nude mice |
686138 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
NAT1 is overexpressed in estrogen receptor-positive breast cancer |
686256 |
1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) |
breast cancer cell |
- |
686604, 688302, 689367 |
3.4.21.106 | hepsin |
breast cancer cell |
upregulation of hepsin mRNA in estrogen receptor alpha-positive breast tumors compared with estrogen receptor alpha-negative breast tumors |
686903 |
1.4.3.13 | protein-lysine 6-oxidase |
breast cancer cell |
- |
687920, 713156 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
breast cancer cell |
17beta-HSD1 is overexpressed in many breast tumors |
688272 |
2.3.1.5 | arylamine N-acetyltransferase |
breast cancer cell |
methylation status and the transcriptional activity of NAT1 in breast cancer tissues: methylation of NAT1 gene is identified in 39 of the breast carcinomas (54.2%), 23 normal (76.7%) and 25 benign breast tissue samples (80.6%). Breast cancer tissues show significantly lower methylation rates of the NAT1 promoters than the normal and benign tissues. Cancer tissues show lower methylation density rates than normal and benign breast tissues. Tissues that show aberrant methylation of NAT1 show significantly less mRNA expression compared with the unmethylated cases. 20 cancers from the methylated group show positive staining for the estrogen receptor (ER) (51.3%), while 72.7% from the unmethylated group stain positive |
689296 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
- |
490103, 672895, 690303, 690447, 701713 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
overexpression of Ron |
690303 |
3.4.21.B41 | kallikrein 10 |
breast cancer cell |
KLK10 is not methylated in normal breast tissues and fibroadenomas while it is in 5 of 10 breast tumors and in 1 of 10 matching normal tissues |
690443 |
3.1.3.11 | fructose-bisphosphatase |
breast cancer cell |
- |
690771 |
3.1.3.16 | protein-serine/threonine phosphatase |
breast cancer cell |
elevated levels of PP5 protein occur in human breast cancer and suggest that PP5 over-expression may aid tumor progression |
691077 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast cancer cell |
in contrast to the expression in ovarian cancer, high expression of KLK 7 is strongly associated with good prognosis in breast cancer patients |
691153 |
5.3.3.8 | DELTA3-DELTA2-enoyl-CoA isomerase |
breast cancer cell |
- |
691485 |
3.4.24.B4 | matrix metalloproteinase-13 |
breast cancer cell |
- |
691486, 712933 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
breast cancer cell |
with a mutation in gene BRCA1 |
691488 |
4.1.1.22 | histidine decarboxylase |
breast cancer cell |
HDC expression is significantly increased in carcinoma cells |
691585 |
3.1.26.5 | ribonuclease P |
breast cancer cell |
- |
691597 |
2.8.2.4 | estrone sulfotransferase |
breast cancer cell |
- |
671361, 676931, 691170, 691624, 693848, 701710, 701711, 761874 |
2.7.7.49 | RNA-directed DNA polymerase |
breast cancer cell |
- |
692248 |
3.2.1.166 | heparanase |
breast cancer cell |
express high levels of endogenous heparanase-1 |
693320 |
2.7.10.1 | receptor protein-tyrosine kinase |
breast cancer cell |
EphA2 forms a complex with ErbB2, resulting in enhanced activation of Ras-MAPK signaling and RhoA GTPase |
693355 |