EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.44 | phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) |
SH-SY5Y cell |
- |
741456 |
1.1.99.24 | hydroxyacid-oxoacid transhydrogenase |
SH-SY5Y cell |
- |
697277 |
1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) |
SH-SY5Y cell |
- |
764767 |
1.11.1.9 | glutathione peroxidase |
SH-SY5Y cell |
- |
712067 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
SH-SY5Y cell |
- |
741945, 742585, 764238 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
SH-SY5Y cell |
- |
753142 |
1.14.14.25 | cholesterol 24-hydroxylase |
SH-SY5Y cell |
- |
684856, 702028, 711641 |
1.14.14.25 | cholesterol 24-hydroxylase |
SH-SY5Y cell |
contains cholesterol 24-hydroxylase mRNA but does not synthesize 24S-hydroxycholesterol |
701715 |
1.14.14.29 | 25/26-hydroxycholesterol 7alpha-hydroxylase |
SH-SY5Y cell |
- |
702427 |
1.14.16.2 | tyrosine 3-monooxygenase |
SH-SY5Y cell |
a dopaminergic-like, neuroblastoma cell line |
687701 |
1.14.16.4 | tryptophan 5-monooxygenase |
SH-SY5Y cell |
- |
684737 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
SH-SY5Y cell |
- |
753142 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
SH-SY5Y cell |
- |
687602, 763665 |
1.3.1.72 | DELTA24-sterol reductase |
SH-SY5Y cell |
- |
688975 |
1.4.3.3 | D-amino-acid oxidase |
SH-SY5Y cell |
- |
763092 |
1.5.3.16 | spermine oxidase |
SH-SY5Y cell |
- |
725069 |
1.6.2.2 | cytochrome-b5 reductase |
SH-SY5Y cell |
- |
741562 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
SH-SY5Y cell |
neuroblastoma cell, cells differentiated by retinoic acid die after exposure to glycated albumin, a model of advanced glycation end product-modified protein. Undifferentiated cells are resistant to glycated albumin. Differentiated cells pre-treated with NAD(P)K oxidase inhibitor diphenyleneiodinium or with rottlerin, an inhibitor of protein kinase C delta, are able to prevent neuronal death induced by glycated albumin |
689213 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
SH-SY5Y cell |
- |
691553 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
SH-SY5Y cell |
- |
698124 |
2.1.1.1 | nicotinamide N-methyltransferase |
SH-SY5Y cell |
- |
756000 |
2.1.1.100 | protein-S-isoprenylcysteine O-methyltransferase |
SH-SY5Y cell |
- |
485044 |
2.1.1.319 | type I protein arginine methyltransferase |
SH-SY5Y cell |
- |
756861 |
2.1.1.320 | type II protein arginine methyltransferase |
SH-SY5Y cell |
- |
734525 |
2.1.1.77 | protein-L-isoaspartate(D-aspartate) O-methyltransferase |
SH-SY5Y cell |
- |
705912, 757812 |
2.1.2.1 | glycine hydroxymethyltransferase |
SH-SY5Y cell |
- |
704566 |
2.3.1.17 | aspartate N-acetyltransferase |
SH-SY5Y cell |
- |
719199 |
2.3.1.256 | N-terminal methionine Nalpha-acetyltransferase NatC |
SH-SY5Y cell |
- |
756860 |
2.3.1.26 | sterol O-acyltransferase |
SH-SY5Y cell |
- |
736702 |
2.3.1.32 | lysine N-acetyltransferase |
SH-SY5Y cell |
neuroblastoma |
704532 |
2.3.1.43 | phosphatidylcholine-sterol O-acyltransferase |
SH-SY5Y cell |
- |
736674, 736889 |
2.3.1.48 | histone acetyltransferase |
SH-SY5Y cell |
neuroblastoma |
704532 |
2.3.1.61 | dihydrolipoyllysine-residue succinyltransferase |
SH-SY5Y cell |
- |
658543 |
2.3.1.7 | carnitine O-acetyltransferase |
SH-SY5Y cell |
- |
703113 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
SH-SY5Y cell |
- |
756392 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
SH-SY5Y cell |
- |
759712 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
SH-SY5Y cell |
neuroblastoma SH-SY5Y cells |
487869 |
2.3.3.16 | citrate synthase (unknown stereospecificity) |
SH-SY5Y cell |
- |
755951 |
2.4.1.90 | N-acetyllactosamine synthase |
SH-SY5Y cell |
- |
735973 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
SH-SY5Y cell |
- |
705072, 735872, 759150 |
2.7.1.107 | diacylglycerol kinase (ATP) |
SH-SY5Y cell |
- |
673918 |
2.7.1.138 | ceramide kinase |
SH-SY5Y cell |
- |
699665, 723271 |
2.7.1.48 | uridine/cytidine kinase |
SH-SY5Y cell |
- |
759866 |
2.7.1.78 | polynucleotide 5'-hydroxyl-kinase |
SH-SY5Y cell |
- |
751906 |
2.7.10.1 | receptor protein-tyrosine kinase |
SH-SY5Y cell |
- |
692018 |
2.7.11.1 | non-specific serine/threonine protein kinase |
SH-SY5Y cell |
neuroblastoma cell line |
662912 |
2.7.11.12 | cGMP-dependent protein kinase |
SH-SY5Y cell |
- |
694559 |
2.7.11.12 | cGMP-dependent protein kinase |
SH-SY5Y cell |
neuroblastoma cell line |
662182 |
2.7.11.13 | protein kinase C |
SH-SY5Y cell |
- |
672842 |
2.7.11.15 | beta-adrenergic-receptor kinase |
SH-SY5Y cell |
neuroblastoma cell line |
662912 |
2.7.11.16 | G-protein-coupled receptor kinase |
SH-SY5Y cell |
neuroblastoma cell line, contains no GRK5 |
662912 |
2.7.11.21 | polo kinase |
SH-SY5Y cell |
- |
761318 |
2.7.11.21 | polo kinase |
SH-SY5Y cell |
neuroblastoma cell |
662229 |
2.7.11.22 | cyclin-dependent kinase |
SH-SY5Y cell |
- |
666467, 680759, 682579, 722194 |
2.7.11.24 | mitogen-activated protein kinase |
SH-SY5Y cell |
- |
692440, 740750 |
2.7.11.26 | tau-protein kinase |
SH-SY5Y cell |
- |
702646, 704555, 705263, 705440, 705916, 706672, 739962, 761718 |
2.7.11.26 | tau-protein kinase |
SH-SY5Y cell |
neuroblastoma cell line |
662690 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
SH-SY5Y cell |
- |
702079 |
2.7.12.1 | dual-specificity kinase |
SH-SY5Y cell |
co-expression experiments in |
693148 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
SH-SY5Y cell |
- |
762284 |
2.7.7.1 | nicotinamide-nucleotide adenylyltransferase |
SH-SY5Y cell |
differentiated |
722694 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
SH-SY5Y cell |
highest expression |
713731 |
3.1.1.1 | carboxylesterase |
SH-SY5Y cell |
- |
729652 |
3.1.1.118 | phospholipid sn-1 acylhydrolase |
SH-SY5Y cell |
- |
761130 |
3.1.1.6 | acetylesterase |
SH-SY5Y cell |
quantitative RT-PCR, Western blot |
696095 |
3.1.1.7 | acetylcholinesterase |
SH-SY5Y cell |
- |
729568 |
3.1.1.7 | acetylcholinesterase |
SH-SY5Y cell |
neuroblastoma-derived cell line |
751284 |
3.1.1.8 | cholinesterase |
SH-SY5Y cell |
- |
751285 |
3.1.2.22 | palmitoyl[protein] hydrolase |
SH-SY5Y cell |
- |
751407 |
3.1.3.11 | fructose-bisphosphatase |
SH-SY5Y cell |
- |
690771 |
3.1.3.32 | polynucleotide 3'-phosphatase |
SH-SY5Y cell |
- |
751906 |
3.1.3.4 | phosphatidate phosphatase |
SH-SY5Y cell |
- |
714316 |
3.1.4.11 | phosphoinositide phospholipase C |
SH-SY5Y cell |
- |
693734 |
3.2.1.169 | protein O-GlcNAcase |
SH-SY5Y cell |
- |
702128 |
3.2.1.18 | exo-alpha-sialidase |
SH-SY5Y cell |
- |
705255 |
3.2.1.18 | exo-alpha-sialidase |
SH-SY5Y cell |
expressing human tyrosinase under the transcriptional control of the T-RExTM. The expression level of Neu4L is dramatically decreased prior to apoptosis. Neu4L and its substrate ganglioside GD3 may act as key molecules in the mitochondrial apoptotic pathway in neuronal cells |
679866 |
3.4.11.14 | cytosol alanyl aminopeptidase |
SH-SY5Y cell |
- |
710523 |
3.4.16.2 | lysosomal Pro-Xaa carboxypeptidase |
SH-SY5Y cell |
- |
683348 |
3.4.17.16 | membrane Pro-Xaa carboxypeptidase |
SH-SY5Y cell |
neuroblastoma cell |
683348 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
SH-SY5Y cell |
- |
681102 |
3.4.21.1 | chymotrypsin |
SH-SY5Y cell |
- |
732856 |
3.4.21.108 | HtrA2 peptidase |
SH-SY5Y cell |
- |
668876, 689124, 732357, 754775 |
3.4.21.26 | prolyl oligopeptidase |
SH-SY5Y cell |
- |
718019, 718171, 754233 |
3.4.21.35 | tissue kallikrein |
SH-SY5Y cell |
- |
731256, 754459 |
3.4.21.69 | Protein C (activated) |
SH-SY5Y cell |
- |
731565 |
3.4.21.B10 | neurosin |
SH-SY5Y cell |
- |
732960, 754959 |
3.4.22.1 | cathepsin B |
SH-SY5Y cell |
a neuroblastoma cell line |
708035 |
3.4.22.38 | cathepsin K |
SH-SY5Y cell |
- |
710073 |
3.4.22.52 | calpain-1 |
SH-SY5Y cell |
neuroblastoma |
680913 |
3.4.22.57 | caspase-4 |
SH-SY5Y cell |
- |
718027 |
3.4.22.60 | caspase-7 |
SH-SY5Y cell |
- |
670408 |
3.4.22.61 | caspase-8 |
SH-SY5Y cell |
- |
709094, 710079 |
3.4.22.64 | caspase-11 |
SH-SY5Y cell |
- |
732944 |
3.4.22.B25 | calpain 5 |
SH-SY5Y cell |
- |
663847, 732139 |
3.4.22.B71 | SENP2 peptidase |
SH-SY5Y cell |
- |
732487 |
3.4.23.45 | memapsin 1 |
SH-SY5Y cell |
- |
711696 |
3.4.23.46 | memapsin 2 |
SH-SY5Y cell |
- |
698448, 698449, 698742, 700411, 700413, 712430, 733384 |
3.4.23.46 | memapsin 2 |
SH-SY5Y cell |
addition of a GPI-anchor to BACE targets the enzyme exclusively to lipid raft domains |
712229 |
3.4.23.46 | memapsin 2 |
SH-SY5Y cell |
in cells overexpressing amyloid precursor protein, thiamine deficiency promotes maturation of beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and increases beta-secretase activity which results in elevated levels of beta-amyloid as well as beta-secretase cleaved C-terminal fragment. An inhibitor of beta-secretase efficiently reduces thiamine deficiency-induced up-regulation of amyloid beta and beta-secretase cleaved fragment |
700413 |
3.4.23.46 | memapsin 2 |
SH-SY5Y cell |
membrane cholesterol significantly influences membrane beta-secretase activity in a biphasic manner, with positive correlations at higher membrane cholesterol levels, and negative correlations at lower membrane cholesterol levels. Pharmacological inhibition of SH-SY5Y beta-secretase activity results in increased membrane cholesterol levels |
699657 |