EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) |
NIH-3T3 cell |
- |
761759 |
1.14.14.14 | aromatase |
NIH-3T3 cell |
- |
765426 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
NIH-3T3 cell |
- |
687570 |
1.17.3.2 | xanthine oxidase |
NIH-3T3 cell |
- |
644638 |
1.3.8.7 | medium-chain acyl-CoA dehydrogenase |
NIH-3T3 cell |
3T3-L1 fibroblast |
656794 |
1.3.99.23 | all-trans-retinol 13,14-reductase |
NIH-3T3 cell |
- |
763769 |
1.4.3.13 | protein-lysine 6-oxidase |
NIH-3T3 cell |
- |
696449 |
1.4.4.2 | glycine dehydrogenase (aminomethyl-transferring) |
NIH-3T3 cell |
- |
724693 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
NIH-3T3 cell |
- |
685335 |
1.8.1.9 | thioredoxin-disulfide reductase |
NIH-3T3 cell |
- |
697613, 711146 |
1.8.1.9 | thioredoxin-disulfide reductase |
NIH-3T3 cell |
TR1 is uniquely overexpressed in cancer cells and its knockdown in a mouse cancer cell line driven by oncogenic k-ras results in orphological changes characteristic of parental (normal) cells, without significant effect on cell growth under normal growth conditions. When grown in serum-deficient medium, TR1 deficient cancer cells lose self-sufficiency of growth, manifest a defective progression in their S phase and a decreased expression of DNA polymerase alpha |
689708 |
2.3.1.48 | histone acetyltransferase |
NIH-3T3 cell |
- |
688978 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
NIH-3T3 cell |
- |
735930, 736442 |
2.3.2.34 | E2 NEDD8-conjugating enzyme |
NIH-3T3 cell |
- |
757647 |
2.4.1.212 | hyaluronan synthase |
NIH-3T3 cell |
- |
690807 |
2.4.1.80 | ceramide glucosyltransferase |
NIH-3T3 cell |
- |
679436 |
2.4.2.30 | NAD+ ADP-ribosyltransferase |
NIH-3T3 cell |
- |
672809 |
2.5.1.46 | deoxyhypusine synthase |
NIH-3T3 cell |
- |
722424 |
2.5.1.75 | tRNA dimethylallyltransferase |
NIH-3T3 cell |
- |
737635 |
2.7.1.107 | diacylglycerol kinase (ATP) |
NIH-3T3 cell |
- |
693319 |
2.7.1.137 | phosphatidylinositol 3-kinase |
NIH-3T3 cell |
- |
660688 |
2.7.1.138 | ceramide kinase |
NIH-3T3 cell |
- |
673703 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
NIH-3T3 cell |
- |
738651 |
2.7.1.40 | pyruvate kinase |
NIH-3T3 cell |
- |
707158, 708413 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
NIH-3T3 cell |
- |
641855, 738599 |
2.7.1.91 | sphingosine kinase |
NIH-3T3 cell |
- |
673473, 706008 |
2.7.1.95 | kanamycin kinase |
NIH-3T3 cell |
transformed with pAG60 |
645101 |
2.7.10.1 | receptor protein-tyrosine kinase |
NIH-3T3 cell |
- |
693142, 705385, 723180 |
2.7.10.1 | receptor protein-tyrosine kinase |
NIH-3T3 cell |
expresses VEGFR-2 |
694119 |
2.7.10.2 | non-specific protein-tyrosine kinase |
NIH-3T3 cell |
- |
693916 |
2.7.11.1 | non-specific serine/threonine protein kinase |
NIH-3T3 cell |
- |
709940 |
2.7.11.1 | non-specific serine/threonine protein kinase |
NIH-3T3 cell |
isozyme PKNalpha |
662053 |
2.7.11.11 | cAMP-dependent protein kinase |
NIH-3T3 cell |
- |
-, 721701 |
2.7.11.13 | protein kinase C |
NIH-3T3 cell |
- |
491115, 676029 |
2.7.11.24 | mitogen-activated protein kinase |
NIH-3T3 cell |
- |
740424 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
NIH-3T3 cell |
- |
665737 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
NIH-3T3 cell |
fibroblast cell line |
665804 |
2.7.11.30 | receptor protein serine/threonine kinase |
NIH-3T3 cell |
fibroblast cell line |
664318 |
2.7.11.4 | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase |
NIH-3T3 cell |
fibroblast cell line |
662283 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
NIH-3T3 cell |
- |
642552 |
2.7.7.14 | ethanolamine-phosphate cytidylyltransferase |
NIH-3T3 cell |
- |
702465, 722415, 737652, 761759 |
2.7.7.19 | polynucleotide adenylyltransferase |
NIH-3T3 cell |
- |
673236 |
2.7.8.11 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase |
NIH-3T3 cell |
- |
645321 |
2.7.9.3 | selenide, water dikinase |
NIH-3T3 cell |
- |
671895 |
2.8.2.20 | protein-tyrosine sulfotransferase |
NIH-3T3 cell |
- |
676006 |
3.1.3.16 | protein-serine/threonine phosphatase |
NIH-3T3 cell |
- |
681877, 709099 |
3.1.3.48 | protein-tyrosine-phosphatase |
NIH-3T3 cell |
- |
652072 |
3.1.4.11 | phosphoinositide phospholipase C |
NIH-3T3 cell |
- |
678395, 678396, 679976, 716113 |
3.1.4.11 | phosphoinositide phospholipase C |
NIH-3T3 cell |
at G1/S boundary of the cell cycle and during quiescence |
682863 |
3.1.4.11 | phosphoinositide phospholipase C |
NIH-3T3 cell |
fibroblasts, treated with insulin-like growth factor 1 |
649261 |
3.1.4.11 | phosphoinositide phospholipase C |
NIH-3T3 cell |
isoenzyme PI-PLC-ß1 |
668867 |
3.1.4.11 | phosphoinositide phospholipase C |
NIH-3T3 cell |
nuclear PLCbeta1 activity is up-regulated two-fold in Swiss 3T3 fibroblasts stimulated with IGF-I |
682863 |
3.1.4.4 | phospholipase D |
NIH-3T3 cell |
- |
664511, 665801, 707550, 707551 |
3.1.4.4 | phospholipase D |
NIH-3T3 cell |
phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells |
664863 |
3.1.6.1 | arylsulfatase (type I) |
NIH-3T3 cell |
- |
709806 |
3.13.2.1 | adenosylhomocysteinase |
NIH-3T3 cell |
- |
697138 |
3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
NIH-3T3 cell |
- |
646631 |
3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
NIH-3T3 cell |
BALB/clone A31 |
646625 |
3.2.2.27 | uracil-DNA glycosylase |
NIH-3T3 cell |
- |
751758 |
3.2.2.29 | thymine-DNA glycosylase |
NIH-3T3 cell |
- |
710145 |
3.3.2.10 | soluble epoxide hydrolase |
NIH-3T3 cell |
embryonic cell line |
661717 |
3.4.11.2 | membrane alanyl aminopeptidase |
NIH-3T3 cell |
fibroblast cell line |
666997 |
3.4.13.9 | Xaa-Pro dipeptidase |
NIH-3T3 cell |
fibroblast cell line |
669598 |
3.4.14.2 | dipeptidyl-peptidase II |
NIH-3T3 cell |
- |
700244 |
3.4.17.17 | tubulinyl-Tyr carboxypeptidase |
NIH-3T3 cell |
- |
647266 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
NIH-3T3 cell |
- |
710366 |
3.4.21.108 | HtrA2 peptidase |
NIH-3T3 cell |
- |
731595 |
3.4.21.6 | coagulation factor Xa |
NIH-3T3 cell |
enzyme elicits a signaling response. ERK1/2 phosphorylation by factor Xa is dependent on protease-activated receptor PAR-2 cleavage and leads to fibroblast proliferation, migration, and differentiation into myofibroblasts |
701355 |
3.4.21.B26 | proprotein convertase 5 |
NIH-3T3 cell |
- |
675967 |
3.4.22.1 | cathepsin B |
NIH-3T3 cell |
- |
697099 |
3.4.22.15 | cathepsin L |
NIH-3T3 cell |
- |
681907, 713582 |
3.4.22.56 | caspase-3 |
NIH-3T3 cell |
- |
699298 |
3.4.22.61 | caspase-8 |
NIH-3T3 cell |
- |
709753 |
3.4.22.B26 | calpain 6 |
NIH-3T3 cell |
- |
717897 |
3.4.22.B75 | SENP7 peptidase |
NIH-3T3 cell |
- |
731614, 732566 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
NIH-3T3 cell |
- |
754128 |
3.4.24.86 | ADAM 17 endopeptidase |
NIH-3T3 cell |
- |
709939 |
3.4.24.B3 | matrix metalloproteinase-11 |
NIH-3T3 cell |
- |
-, 708156 |
3.4.25.1 | proteasome endopeptidase complex |
NIH-3T3 cell |
- |
712388 |
3.5.4.16 | GTP cyclohydrolase I |
NIH-3T3 cell |
transfected with a tet-off plasmid and a plasmid encoding human GCH1, the stable clone is named tet-GCH cell |
698891 |
3.6.1.13 | ADP-ribose diphosphatase |
NIH-3T3 cell |
- |
740674 |
3.6.4.13 | RNA helicase |
NIH-3T3 cell |
- |
711701, 756594 |
3.6.4.B1 | kinesin K16 |
NIH-3T3 cell |
- |
668197 |
3.6.5.2 | small monomeric GTPase |
NIH-3T3 cell |
- |
697169 |
4.1.1.17 | ornithine decarboxylase |
NIH-3T3 cell |
- |
696087 |
4.1.1.17 | ornithine decarboxylase |
NIH-3T3 cell |
overexpression of constitutively active Ras12V results in up to 20fold increase of enzyme activity due to increase in enzyme transcription and translation |
663927 |
4.1.1.50 | adenosylmethionine decarboxylase |
NIH-3T3 cell |
- |
704069 |
4.1.2.27 | sphinganine-1-phosphate aldolase |
NIH-3T3 cell |
- |
714674 |
4.3.2.9 | gamma-glutamylcyclotransferase |
NIH-3T3 cell |
- |
735948, 743139 |
5.6.1.3 | plus-end-directed kinesin ATPase |
NIH-3T3 cell |
- |
668197 |
5.6.2.1 | DNA topoisomerase |
NIH-3T3 cell |
mouse embryonic fibroblast cell line |
690782 |
5.6.2.1 | DNA topoisomerase |
NIH-3T3 cell |
mouse immortalized fibroblasts |
691619 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
NIH-3T3 cell |
- |
691211 |
6.3.2.3 | glutathione synthase |
NIH-3T3 cell |
- |
692439 |
7.3.2.1 | ABC-type phosphate transporter |
NIH-3T3 cell |
- |
719237 |
7.4.2.3 | mitochondrial protein-transporting ATPase |
NIH-3T3 cell |
- |
673805 |
7.6.2.2 | ABC-type xenobiotic transporter |
NIH-3T3 cell |
- |
210397, 712710 |
7.6.2.2 | ABC-type xenobiotic transporter |
NIH-3T3 cell |
NIH 3T3 MRP transfectant pSRalpha-MRP-32 cells |
210398 |