EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.205 | IMP dehydrogenase |
CHO cell |
- |
347910 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
CHO cell |
- |
654824 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
CHO cell |
- |
675520 |
1.14.13.9 | kynurenine 3-monooxygenase |
CHO cell |
- |
742349 |
1.14.18.2 | CMP-N-acetylneuraminate monooxygenase |
CHO cell |
generation of a stable CHO cell line with significantly reduced levels of CMP-Neu5Ac hydroxylase activity and reduced amounts of N-glycolylneuraminic acid, using a rational antisense RNA strategy |
658179 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
CHO cell |
- |
437919 |
1.3.1.72 | DELTA24-sterol reductase |
CHO cell |
- |
724442 |
1.3.5.1 | succinate dehydrogenase |
CHO cell |
- |
654199 |
1.7.3.3 | factor-independent urate hydroxylase |
CHO cell |
wild-type and PEX5-defective CHO cell lines each stable producing the enzyme |
657736 |
2.3.1.26 | sterol O-acyltransferase |
CHO cell |
- |
486693, 486703, 674216 |
2.3.1.26 | sterol O-acyltransferase |
CHO cell |
CHO cells, cultured cells |
486677, 486690 |
2.3.1.50 | serine C-palmitoyltransferase |
CHO cell |
- |
658109, 659868 |
2.3.1.57 | diamine N-acetyltransferase |
CHO cell |
- |
487265, 662129 |
2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
CHO cell |
wild-type and mutant F6 and F8 |
488371 |
2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
CHO cell |
wild-type, Lec1 cells are deficient in enzyme activity, mutant Lec1A cells show weak enzyme activity, 2% compared to wild-type, and produce complex N-glycans |
488380 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
CHO cell |
- |
638279 |
2.4.1.135 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase |
CHO cell |
- |
659141, 659435 |
2.4.1.141 | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase |
CHO cell |
- |
685092 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
CHO cell |
- |
638214 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
CHO cell |
LEC10 ovary cell line |
488370 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
CHO cell |
ricin resistant mutant |
488370 |
2.4.1.149 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase |
CHO cell |
Pro-5 and Lec2 CHO cells |
638584 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
CHO cell |
- |
736218 |
2.4.1.198 | phosphatidylinositol N-acetylglucosaminyltransferase |
CHO cell |
CHO-K1 cell lines G9PLAP and mutant G9PLAP.85 |
638133 |
2.4.1.221 | peptide-O-fucosyltransferase |
CHO cell |
- |
441440, 441442, 703986 |
2.4.1.221 | peptide-O-fucosyltransferase |
CHO cell |
fucosylation-deficient Lec13 chinese hamster ovary cells have wild-type levels of Pofut1 and cell surface Notch receptors |
704420 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
CHO cell |
- |
675791 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
CHO cell |
- |
441440, 441442, 702784 |
2.4.1.80 | ceramide glucosyltransferase |
CHO cell |
strain K1, and GM3-mutant strain Z65 |
489424 |
2.4.1.83 | dolichyl-phosphate beta-D-mannosyltransferase |
CHO cell |
- |
658867 |
2.4.1.83 | dolichyl-phosphate beta-D-mannosyltransferase |
CHO cell |
CHO 2.38 cel |
680743 |
2.4.1.90 | N-acetyllactosamine synthase |
CHO cell |
- |
675952 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
CHO cell |
- |
722180 |
2.4.2.8 | hypoxanthine phosphoribosyltransferase |
CHO cell |
- |
701888 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
CHO cell |
- |
721384 |
2.5.1.26 | alkylglycerone-phosphate synthase |
CHO cell |
- |
702411 |
2.6.1.2 | alanine transaminase |
CHO cell |
- |
737896 |
2.7.1.138 | ceramide kinase |
CHO cell |
- |
690700 |
2.7.1.20 | adenosine kinase |
CHO cell |
- |
641111, 660724, 663319 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
CHO cell |
- |
723136 |
2.7.11.11 | cAMP-dependent protein kinase |
CHO cell |
- |
661759 |
2.7.7.15 | choline-phosphate cytidylyltransferase |
CHO cell |
- |
721712 |
2.7.7.19 | polynucleotide adenylyltransferase |
CHO cell |
- |
642938 |
2.7.7.30 | fucose-1-phosphate guanylyltransferase |
CHO cell |
- |
645224 |
2.7.7.43 | N-acylneuraminate cytidylyltransferase |
CHO cell |
- |
645275 |
2.7.8.1 | ethanolaminephosphotransferase |
CHO cell |
- |
644415 |
2.7.8.15 | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase |
CHO cell |
- |
645359, 645360, 645364, 645366, 645367, 703322 |
2.7.8.27 | sphingomyelin synthase |
CHO cell |
- |
667767 |
2.7.8.29 | L-serine-phosphatidylethanolamine phosphatidyltransferase |
CHO cell |
- |
661228, 717758, 717761 |
2.7.8.5 | CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase |
CHO cell |
- |
644299 |
2.8.2.8 | [heparan sulfate]-glucosamine N-sulfotransferase |
CHO cell |
- |
645941 |
3.1.2.2 | palmitoyl-CoA hydrolase |
CHO cell |
- |
646175 |
3.1.2.20 | acyl-CoA hydrolase |
CHO cell |
- |
646175 |
3.1.22.1 | deoxyribonuclease II |
CHO cell |
- |
696131 |
3.1.3.35 | thymidylate 5'-phosphatase |
CHO cell |
- |
81087 |
3.1.3.36 | phosphoinositide 5-phosphatase |
CHO cell |
- |
677869 |
3.1.3.4 | phosphatidate phosphatase |
CHO cell |
- |
690815 |
3.1.4.3 | phospholipase C |
CHO cell |
stably expressing human imidazoline receptor antisera-selected protein IRAS |
681028 |
3.2.1.106 | mannosyl-oligosaccharide glucosidase |
CHO cell |
- |
694198 |
3.2.1.166 | heparanase |
CHO cell |
- |
690796, 692520 |
3.2.1.18 | exo-alpha-sialidase |
CHO cell |
- |
655170, 655171 |
3.4.11.3 | cystinyl aminopeptidase |
CHO cell |
- |
731661 |
3.4.16.6 | carboxypeptidase D |
CHO cell |
- |
753046 |
3.4.17.12 | carboxypeptidase M |
CHO cell |
- |
696532 |
3.4.17.22 | metallocarboxypeptidase D |
CHO cell |
- |
753046 |
3.4.21.112 | site-1 protease |
CHO cell |
- |
710345 |
3.4.21.75 | Furin |
CHO cell |
- |
681690, 700401 |
3.4.22.15 | cathepsin L |
CHO cell |
- |
753061 |
3.4.22.56 | caspase-3 |
CHO cell |
- |
696881 |
3.4.22.60 | caspase-7 |
CHO cell |
- |
696881 |
3.4.22.61 | caspase-8 |
CHO cell |
- |
666402 |
3.4.22.61 | caspase-8 |
CHO cell |
inhibition of caspase-8 enhances the viability of the CHO cells in both batch and fed-batch suspension cultures. Caspase-8 is possible involved in the apoptotic cell death in batch and fed-batch cultures of CHO cells |
681759 |
3.4.22.62 | caspase-9 |
CHO cell |
inhibition of caspase-9 enhances the viability of the CHO cells in both batch and fed-batch suspension cultures. Caspase-9 is possible involved in the apoptotic cell death in batch and fed-batch cultures of CHO cells |
681759 |
3.4.23.46 | memapsin 2 |
CHO cell |
- |
711091, 711303, 734729 |
3.4.23.46 | memapsin 2 |
CHO cell |
inhibitor drugs tested |
683381 |
3.4.23.5 | cathepsin D |
CHO cell |
- |
711533, 753060 |
3.4.24.85 | S2P endopeptidase |
CHO cell |
- |
735261 |
3.4.24.86 | ADAM 17 endopeptidase |
CHO cell |
- |
669269 |
3.4.24.86 | ADAM 17 endopeptidase |
CHO cell |
mutated sublines M1 and M2. M1 contains only one expressible TACE allele encoding an M435I point mutation in the catalytic center of the protease, and M2 cells produce two TACE variants with distinct point mutations in the catalytic domain (C22Y) and the cysteine-rich/disintegrin domain (C600Y) |
669237 |
3.5.1.23 | ceramidase |
CHO cell |
- |
697229 |
3.6.5.2 | small monomeric GTPase |
CHO cell |
- |
665471, 719932 |
3.6.5.5 | dynamin GTPase |
CHO cell |
- |
686581 |
4.1.1.21 | phosphoribosylaminoimidazole carboxylase |
CHO cell |
accumulates 5-aminoimidazole ribotide |
728311 |
4.6.1.1 | adenylate cyclase |
CHO cell |
- |
679659, 695074 |
4.6.1.1 | adenylate cyclase |
CHO cell |
expresses all nine adenylate cyclase isoforms |
678381 |
5.1.3.7 | UDP-N-acetylglucosamine 4-epimerase |
CHO cell |
ldlD cells are deficient in UDP-N-acetylglucosamine 4-epimerase |
2410 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
CHO cell |
- |
691628 |
6.1.1.1 | tyrosine-tRNA ligase |
CHO cell |
- |
745300 |
6.1.1.20 | phenylalanine-tRNA ligase |
CHO cell |
- |
744547 |
6.1.1.4 | leucine-tRNA ligase |
CHO cell |
- |
693164 |
6.3.2.17 | tetrahydrofolate synthase |
CHO cell |
- |
744775 |
6.3.3.2 | 5-formyltetrahydrofolate cyclo-ligase |
CHO cell |
CHO, ovary cell line and its methotrexate resistant subline |
1327 |
7.2.2.9 | P-type Cu2+ transporter |
CHO cell |
copper-resistant CHO cells which overexpress the enzyme |
246912 |
7.6.2.1 | P-type phospholipid transporter |
CHO cell |
- |
720146 |
7.6.2.2 | ABC-type xenobiotic transporter |
CHO cell |
- |
733268 |