EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.4.19.9 | folate gamma-glutamyl hydrolase |
breast cancer cell |
- |
683368 |
3.4.21.106 | hepsin |
breast cancer cell |
upregulation of hepsin mRNA in estrogen receptor alpha-positive breast tumors compared with estrogen receptor alpha-negative breast tumors |
686903 |
3.4.21.109 | matriptase |
breast cancer cell |
- |
683364, 683489, 683492, 683494, 683763, 683893, 695463, 717902 |
3.4.21.109 | matriptase |
breast cancer cell |
strong expression association between matriptase and its substrate prostasin in breast cancer |
717902 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast cancer cell |
- |
707996 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast cancer cell |
enzyme expression analysis in 155 patients, overview |
664622 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast cancer cell |
in contrast to the expression in ovarian cancer, high expression of KLK 7 is strongly associated with good prognosis in breast cancer patients |
691153 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
breast cancer cell |
lymph node metastasis |
707996 |
3.4.21.35 | tissue kallikrein |
breast cancer cell |
- |
678522, 752895 |
3.4.21.45 | complement factor I |
breast cancer cell |
- |
753137 |
3.4.21.59 | Tryptase |
breast cancer cell |
significantly more tryptase in peritumoral tissue than in normal breast tissue |
710170 |
3.4.21.61 | Kexin |
breast cancer cell |
- |
754945 |
3.4.21.73 | u-Plasminogen activator |
breast cancer cell |
- |
709912, 710163 |
3.4.21.75 | Furin |
breast cancer cell |
- |
707598, 708162, 708242, 708753 |
3.4.21.B25 | PACE4 proprotein convertase |
breast cancer cell |
- |
679039 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
breast cancer cell |
- |
672907 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
breast cancer cell |
FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival |
731551 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast cancer cell |
expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7 expression and and clinicopathological factors. mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, overview. mRNA levels of KLK5 and KLK7 are both downregulated in breast cancers relative to normal and benign tissues, and downregulated in metastases compared to primary cancers |
707996 |
3.4.21.B39 | stratum corneum tryptic enzyme |
breast cancer cell |
no expression |
670978 |
3.4.21.B41 | kallikrein 10 |
breast cancer cell |
- |
678524, 678530, 679256 |
3.4.21.B41 | kallikrein 10 |
breast cancer cell |
downregulation due to hypermethylation of exon 3 |
667874 |
3.4.21.B41 | kallikrein 10 |
breast cancer cell |
KLK10 is not methylated in normal breast tissues and fibroadenomas while it is in 5 of 10 breast tumors and in 1 of 10 matching normal tissues |
690443 |
3.4.21.B43 | kallikrein 12 |
breast cancer cell |
- |
679276 |
3.4.21.B43 | kallikrein 12 |
breast cancer cell |
enzyme splice variant KLK12sv3 is more frequently expressed in tumors of lower grade, early patient TNM stage, and smaller tumor size, overview |
732958 |
3.4.21.B45 | kallikrein 14 |
breast cancer cell |
KLK14 expression significantly higher compared to normal breast tissues |
668103 |
3.4.21.B6 | prostasin |
breast cancer cell |
strong expression association between matriptase and its substrate prostasin in breast cancer |
717902 |
3.4.22.1 | cathepsin B |
breast cancer cell |
- |
36625, 753138 |
3.4.22.15 | cathepsin L |
breast cancer cell |
- |
752936, 755110 |
3.4.22.26 | cancer procoagulant |
breast cancer cell |
- |
668137 |
3.4.22.34 | Legumain |
breast cancer cell |
legumain is overexpressed in the majority of human solid tumours, including breast cancer, colorectal cancer, ovarian cancer, prostate cancer and gastric cancer |
752851 |
3.4.22.38 | cathepsin K |
breast cancer cell |
biopsy sites, benign lesions, ductal carcinoma in situ, and invasive breast tumors of different stages. Neither epithelial nor stromal expression of CTSK is significantly associated with recurrence-free or overall survival |
697375 |
3.4.22.41 | cathepsin F |
breast cancer cell |
- |
668085 |
3.4.22.49 | separase |
breast cancer cell |
increased expression of separase |
697382 |
3.4.22.49 | separase |
breast cancer cell |
overexpressed in numerous human cancers including breast, bone, brain, and prostate |
752903 |
3.4.22.49 | separase |
breast cancer cell |
Separase is significantly overexpressed in human breast tumors compared with matched normal tissue (Western blot) |
700945 |
3.4.22.52 | calpain-1 |
breast cancer cell |
- |
710164 |
3.4.22.53 | calpain-2 |
breast cancer cell |
- |
732050 |
3.4.22.56 | caspase-3 |
breast cancer cell |
- |
695620, 696872, 697055 |
3.4.22.56 | caspase-3 |
breast cancer cell |
a breast cancer Dox resistant MCF-7/Dox cell line |
697054 |
3.4.22.59 | caspase-6 |
breast cancer cell |
- |
647467 |
3.4.22.59 | caspase-6 |
breast cancer cell |
invasive operable pT1 and pT2 ductal breast carcinoma are analysed of 210 patients: caspase-6 is overexpressed in 52.9% |
680072 |
3.4.22.61 | caspase-8 |
breast cancer cell |
- |
695620, 697053, 697261 |
3.4.22.62 | caspase-9 |
breast cancer cell |
- |
717277, 731452 |
3.4.22.63 | caspase-10 |
breast cancer cell |
- |
710209 |
3.4.22.B29 | calpain 9 |
breast cancer cell |
expression analysis |
731549 |
3.4.22.B70 | SENP1 peptidase |
breast cancer cell |
enzyme SENP1 levels are positively correlated with substrate Pin1 levels in human breast cancer specimens |
731577 |
3.4.22.B71 | SENP2 peptidase |
breast cancer cell |
weak expression, benign breast adenofibroma cell and malignant breast cancer tissue |
732727 |
3.4.22.B75 | SENP7 peptidase |
breast cancer cell |
- |
731599, 732812 |
3.4.23.3 | gastricsin |
breast cancer cell |
- |
668809 |
3.4.23.36 | Signal peptidase II |
breast cancer cell |
- |
754940 |
3.4.23.5 | cathepsin D |
breast cancer cell |
- |
695419, 695654, 711855, 755627 |
3.4.23.B24 | signal peptide peptidase |
breast cancer cell |
high expression level |
754940 |
3.4.24.18 | meprin A |
breast cancer cell |
- |
733064 |
3.4.24.23 | matrilysin |
breast cancer cell |
early stage primary cancers, MMP-7 correlates with breast cancer development, overexpression of MMP-7 and ErbB4, overview |
683331 |
3.4.24.35 | gelatinase B |
breast cancer cell |
- |
696965, 708409, 709302, 710245 |
3.4.24.35 | gelatinase B |
breast cancer cell |
primary breast tumor cell |
696965 |
3.4.24.56 | insulysin |
breast cancer cell |
- |
683571 |
3.4.24.7 | interstitial collagenase |
breast cancer cell |
- |
708587, 710246 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
breast cancer cell |
- |
638810, 708543, 754158 |
3.4.24.82 | ADAMTS-4 endopeptidase |
breast cancer cell |
- |
754958 |
3.4.24.B10 | ADAM12 endopeptidase |
breast cancer cell |
- |
670445, 719935, 754703, 754704, 755485 |
3.4.24.B10 | ADAM12 endopeptidase |
breast cancer cell |
primary breast cancer cell BC1205 |
755485 |
3.4.24.B10 | ADAM12 endopeptidase |
breast cancer cell |
primary breast cancer cell BC1302 |
755485 |
3.4.24.B3 | matrix metalloproteinase-11 |
breast cancer cell |
- |
708156, 753930 |
3.4.24.B3 | matrix metalloproteinase-11 |
breast cancer cell |
breast tumor tissues display higher expression levels of MMP-11 than the adjacent non-cancerous tissues |
708173 |
3.4.24.B3 | matrix metalloproteinase-11 |
breast cancer cell |
cancer cell-adipocyte interaction/crosstalk during the initial steps of cancer cell invasion |
668150 |
3.4.24.B3 | matrix metalloproteinase-11 |
breast cancer cell |
samples from patients with histologically confirmed diagnosis of early invasive breast cancers of ductal types, expression of MMP-11 is increased and more heterogeneous in metastatic specimens compared to non-metastatic tumour samples, quantitative expression and mapping of the cancer biomarker MMP-11 in human breast cancer tissue sections, overview |
752463 |
3.4.24.B4 | matrix metalloproteinase-13 |
breast cancer cell |
- |
691486, 712933 |
3.4.24.B4 | matrix metalloproteinase-13 |
breast cancer cell |
expression of MMP13 in tumors |
711675 |
3.4.24.B7 | matrix metalloproteinase-26 |
breast cancer cell |
elevated MMP-26 expression level |
710794 |
3.5.1.12 | biotinidase |
breast cancer cell |
analysis of gene expression in breast cancer plasma, diverse tissue samples, profiling, overview |
711589 |
3.5.1.2 | glutaminase |
breast cancer cell |
- |
670391, 694485 |
3.5.1.23 | ceramidase |
breast cancer cell |
- |
733498 |
3.5.1.98 | histone deacetylase |
breast cancer cell |
- |
711660 |
3.5.2.9 | 5-oxoprolinase (ATP-hydrolysing) |
breast cancer cell |
- |
694485 |
3.5.4.4 | adenosine deaminase |
breast cancer cell |
- |
718704 |
3.5.4.4 | adenosine deaminase |
breast cancer cell |
the activity of isozyme ADA2 is increased |
668272 |
3.6.1.62 | 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase |
breast cancer cell |
- |
758325 |
3.6.4.13 | RNA helicase |
breast cancer cell |
- |
756284 |
3.6.4.13 | RNA helicase |
breast cancer cell |
deregulated expression of p68 in breast cancer. The DDX5 locus is consistently strengthened in breast cancer and is usually overexpressed in association with ERBB2. Various breast cancer cell lines exhibit different dependence on DDX5 expression |
757299 |
3.6.4.B10 | chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing) |
breast cancer cell |
- |
756668 |
3.6.5.2 | small monomeric GTPase |
breast cancer cell |
mRNA levels of RasL10B are down-regulated in all breast cancer cells tested (HBL100, MCF7, MDA-MB-468, MDA-MB-231 and MDA-MB-435. RasL10B) is a member of ras superfamily with tumor suppressor potential |
668060 |
4.1.1.17 | ornithine decarboxylase |
breast cancer cell |
- |
682982, 695299 |
4.1.1.22 | histidine decarboxylase |
breast cancer cell |
HDC expression is significantly increased in carcinoma cells |
691585 |
4.1.1.28 | aromatic-L-amino-acid decarboxylase |
breast cancer cell |
different splicing variants |
748845 |
4.1.1.9 | malonyl-CoA decarboxylase |
breast cancer cell |
- |
706013 |
4.2.1.11 | phosphopyruvate hydratase |
breast cancer cell |
- |
702980 |
4.2.1.11 | phosphopyruvate hydratase |
breast cancer cell |
cell surface ENOA is enhanced |
714970 |
4.3.2.1 | argininosuccinate lyase |
breast cancer cell |
the enzynme is overexpressed in breast cancer |
748794 |
4.3.2.9 | gamma-glutamylcyclotransferase |
breast cancer cell |
- |
687744, 705761, 720332, 735747 |
4.4.1.5 | lactoylglutathione lyase |
breast cancer cell |
MDA-MD-231 cell, JIMT-1 cell |
694824 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
breast cancer cell |
- |
681814, 727322 |
5.2.1.8 | peptidylprolyl isomerase |
breast cancer cell |
- |
705066 |
5.3.1.9 | glucose-6-phosphate isomerase |
breast cancer cell |
- |
703022 |
5.3.3.12 | L-dopachrome isomerase |
breast cancer cell |
- |
748797 |
5.3.3.8 | DELTA3-DELTA2-enoyl-CoA isomerase |
breast cancer cell |
- |
691485 |
5.6.2.1 | DNA topoisomerase |
breast cancer cell |
- |
750368 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
breast cancer cell |
- |
693362, 727888 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
breast cancer cell |
with a mutation in gene BRCA1 |
691488 |
6.2.1.15 | arachidonate-CoA ligase |
breast cancer cell |
a breast cancer cell model, comprising different cell lines, expresses ACSL4 in all cell lines, high expression level |
716687 |